LitCovid-sentences  

PMC:7546716 / 7433-9661 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T24 0-40 Sentence denotes Figure 1 T-cell polarisation in COVID-19
T25 41-214 Sentence denotes IL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs.
T26 215-350 Sentence denotes IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9.
T27 351-523 Sentence denotes IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10.
T28 524-707 Sentence denotes IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells.
T29 708-817 Sentence denotes Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages.
T30 818-1037 Sentence denotes In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells.
T31 1038-1275 Sentence denotes At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6.
T32 1276-1478 Sentence denotes IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF.
T33 1479-1568 Sentence denotes In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages.
T34 1569-1602 Sentence denotes CCR=C-C motif chemokine receptor.
T35 1603-1634 Sentence denotes CCL=C-C motif chemokine ligand.
T36 1635-1669 Sentence denotes CXCL=C-X-C motif chemokine ligand.
T37 1670-1700 Sentence denotes CXCR=C-X-C chemokine receptor.
T38 1701-1727 Sentence denotes Foxp=forkhead box protein.
T39 1728-1753 Sentence denotes GATA=GATA-binding factor.
T40 1754-1810 Sentence denotes GM-CSF=granulocyte-macrophage colony-stimulating factor.
T41 1811-1826 Sentence denotes IL=interleukin.
T42 1827-1860 Sentence denotes ILC2=type 2 innate lymphoid cell.
T43 1861-1916 Sentence denotes MyD88=myeloid differentiation primary response protein.
T44 1917-1946 Sentence denotes NF-κB=nuclear factor-kappa B.
T45 1947-1999 Sentence denotes NLRP=NACHT, LRR, and PYD domains-containing protein.
T46 2000-2031 Sentence denotes PU.1=transcription factor PU.1.
T47 2032-2064 Sentence denotes RORC=nuclear receptor ROR-gamma.
T48 2065-2082 Sentence denotes ST2=ST2 receptor.
T49 2083-2134 Sentence denotes STAT=signal transducer and transcription activator.
T50 2135-2166 Sentence denotes TGF=transforming growth factor.
T51 2167-2179 Sentence denotes Th=T-helper.
T52 2180-2204 Sentence denotes TLR=toll-like receptors.
T53 2205-2228 Sentence denotes Treg=regulatory T cell.