PMC:7546130 / 1754-6604 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T13 0-11 Sentence denotes Case report
T14 12-192 Sentence denotes On March 25, a 68-year-old man with previous history of hypertension and diabetes mellitus presented to the emergency department with dyspnea, fever, fatigue, and productive cough.
T15 193-345 Sentence denotes Diagnosis of coronavirus 2 (SARS-CoV-2) pneumonia was confirmed by nasopharyngeal swab specimen using the transcriptase-polymerase chain reaction assay.
T16 346-592 Sentence denotes Following the development of severe acute respiratory syndrome and acute kidney failure, the patient was admitted to our intensive care unit (ICU) and intubated; mechanical ventilation and continuous veno-venous hemodialysis (CVVHD) were started.
T17 593-704 Sentence denotes Table 1 reports the main mechanical ventilation settings, data on respiratory function, and laboratory results.
T18 705-769 Sentence denotes He was started on steroids, hydroxychloroquine, and ceftaroline.
T19 770-896 Sentence denotes A prophylactic dose of enoxaparin (6000 u once/day) was subsequently switched to 6000 u/bd, due to increase of D-dimer values.
T20 897-1042 Sentence denotes Respiratory function improved over days, and he was switched to assisted mechanical ventilation, while CVVHD was continued for persistent anuria.
T21 1043-1127 Sentence denotes On day 9, on sedation hold, his Glasgow Coma Score was 3 (Eyes 1,Verbal 1, Motor 1).
T22 1128-1215 Sentence denotes Photomotor reflex was present, and brainstem reflexes (including cough) were preserved.
T23 1216-1478 Sentence denotes After 2 days from sedation hold, an electroencephalography (EEG) revealed a severe voltage attenuation (signal diffusely < 20 μV), with background activity substituted by irregular theta and delta activities widely distributed, without antero-posterior gradient.
T24 1479-1582 Sentence denotes No focal or generalized interictal/ictal epileptiform discharges nor periodic discharges were observed.
T25 1583-1642 Sentence denotes Two days later, a second EEG showed no significant changes.
T26 1643-1893 Sentence denotes At brain MRI (Fig. 1), DWI shows multiple small supratentorial areas of restricted diffusion, consistent with acute ischemic foci, involving the bilateral fronto-parietal deep and subcortical white matter and the genu and body of the corpus callosum.
T27 1894-2012 Sentence denotes SWI revealed several hypointense foci throughout the brain, both infratentorial and supratentorial, mostly bithalamic.
T28 2013-2146 Sentence denotes On T1-weighted images obtained after intravenous gadolinium injection, there was no evidence of parenchymal or meningeal enhancement.
T29 2147-2395 Sentence denotes Cerebrospinal fluid (CSF) analysis showed 0.492 g/L [0.130–0.520 g/L] proteins, 88 mg/dL [44–74 mg/L] glucose, no leukocytes and red blood cells, CSF/serum albumin ratio 7.74 [1.92–7.30], and CSF/serum immunoglobulin G (IgG) ratio 4.48 [0.82–3.26].
T30 2396-2435 Sentence denotes SARS-CoV-2 RNA was detected in the CSF.
T31 2436-2539 Sentence denotes Over the following days, the patient developed a systemic candida and gram-negative bacteria infection.
T32 2540-2645 Sentence denotes His respiratory function significantly worsened, and he developed a septic shock with multiorgan failure.
T33 2646-2664 Sentence denotes He died on day 21.
T34 2665-2739 Sentence denotes Table 1 Laboratory data, respiratory function, and mechanical ventilation†
T35 2740-2816 Sentence denotes Variable Reference range, adults On admission ICU day 3 ICU day 7 ICU day 14
T36 2817-2874 Sentence denotes White blood cell (109/L) 4.50–9.80 9.58 13.99 24.14 23.58
T37 2875-2925 Sentence denotes C-reactive protein (mg/L) 0.0–5.0 137 77.7 138 121
T38 2926-2977 Sentence denotes Procalcitonin (mcg/L) 0.00–0.25 1.37 2.09 1.67 2.07
T39 2978-3024 Sentence denotes IL (interleukin)-6 (ng/L) < 3.4 491 32.7 NA NA
T40 3025-3062 Sentence denotes Ferritin (mcg/L) 30–400 605 378 NA NA
T41 3063-3108 Sentence denotes D-Dimer (mcg/L) 0.00–500.0 1605 810 3497 6941
T42 3109-3155 Sentence denotes Fibrinogen (g/L) 2.00–4.00 6.10 3.84 6.06 8.47
T43 3156-3227 Sentence denotes Activated partial-thromboplastin time (sec) 28.0–40.0 39 27.3 33.6 32.2
T44 3228-3270 Sentence denotes Creatinine (mg/dL) 0.51–0.95 2.4 5 2.9 2.6
T45 3271-3313 Sentence denotes Urea nitrogen (mg/dL) 21–54 90 172 135 167
T46 3314-3365 Sentence denotes Lactate dehydrogenase (U/L) 135–214 425 282 357 265
T47 3366-3407 Sentence denotes Arterial pH 7.35–7.45 7.36 7.35 7.23 7.34
T48 3408-3477 Sentence denotes Arterial partial pressure of oxygen (mmHg) 83–108 71.8 73.3 80.8 56.1
T49 3478-3554 Sentence denotes Arterial partial pressure of carbon dioxide (mmHg) 32–45 42.4 48.1 54.1 55.4
T50 3555-3595 Sentence denotes Lactate (mmol/L) 0.5–1.6 1.1 1.1 1.6 0.8
T51 3596-3690 Sentence denotes Nasopharyngeal swab Positive-quite positive-negative Positive Positive Positive Quite positive
T52 3691-3749 Sentence denotes Ventilation mode Controlled Controlled Controlled Assisted
T53 3750-3793 Sentence denotes Fraction of inspired oxygen 0.8 0.6 0.6 0.6
T54 3794-3846 Sentence denotes Positive end-expiratory pressure (cmH2O) 15 15 13 12
T55 3847-3898 Sentence denotes Continuous renal replacement therapy NO YES YES YES
T56 3899-3983 Sentence denotes †To convert the values for urea nitrogen to millimoles per liter, multiply by 0.357.
T57 3984-4059 Sentence denotes To convert values for creatinine to micromoles per liter, multiply by 88.4.
T58 4060-4084 Sentence denotes NA denotes not available
T59 4085-4349 Sentence denotes Fig. 1 Diffusion-weighted imaging (DWI) b1000 (a) and apparent diffusion coefficient map (b) show multiple areas of restricted diffusion, involving the bilateral fronto-parietal white matter and the genu of the corpus callosum, compatible with acute ischemic foci.
T60 4350-4646 Sentence denotes Susceptibility-weighted imaging (SWI) (c) shows several millimetric hypointense areas, predominantly distributed in the thalami bilaterally, but also in the genu of the corpus callosum and in the parietal iuxtacortical white matter, consistent with microhemorrhages or alternatively microthrombi.
T61 4647-4850 Sentence denotes T1-weighted post-contrast image (d) demonstrates the lack of parenchymal or meningeal enhancement at the level of these lesions (lack of enhancement was also observed in the rest of the brain, not shown)