LitCovid-sentences  

PMC:7544943 / 18160-19546 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T165 0-4 Sentence denotes 3.2.
T166 6-19 Sentence denotes Lipophilicity
T167 20-156 Sentence denotes Lipophilicity or fat friendliness of a molecule defines the dissolving capability in fat, oil or any non-polar solvent (Lindsley, 2010).
T168 157-280 Sentence denotes The water n-octanol partition coefficient (log Po/w) is used as the measure of lipophilicity (Constantinescu et al., 2019).
T169 281-409 Sentence denotes Various computational methods are developed for the estimation of log Po/w for diverse performance upon different chemical sets.
T170 410-745 Sentence denotes The SwissADME provides five different predictive models such as XLOGP3 (Cheng et al., 2007), WLOGP (Wildman & Crippen, 1999), MLOGP (Moriguchi et al., 1992), SILICOS-IT (http://silicos-it.be.s3-website-eu-west-1.amazonaws.com/software/filter-it/1.0.2/filter-it.html, 2016) and iLOGP (Daina et al., 2014) for better prediction accuracy.
T171 746-873 Sentence denotes Predicted lipophilicity (Log P) values of the spice molecules obtained from different calculation models are shown in Figure 1.
T172 874-1107 Sentence denotes All the molecules subjected to lipophilicity test lie in the range of +1.2 to +4.19 of consensus value that obeys the Lipinski’s limit of log p < 5, which suggests they can be used for further clinical trials (Arnott & Planey, 2012).
T173 1108-1218 Sentence denotes The lowest lipophilicity is observed for Vanillin and the highest for Nerolidol, among the screened molecules.
T174 1219-1310 Sentence denotes From Figure 1, it is found that all the ligand molecules have positive lipophilicity value.
T175 1311-1386 Sentence denotes Hence, these molecules satisfy the essential criteria to be drug molecules.