LitCovid-sentences  

PMC:7543426 / 9886-20816 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T108 0-35 Sentence denotes Autopsy and Microscopic Examination
T109 37-50 Sentence denotes Lung Findings
T110 52-73 Sentence denotes Macroscopic Findings.
T111 74-208 Sentence denotes Lungs from all patients were increased in volume, firm, edematous, and congested with diffuse pleural thickening and pleural effusion.
T112 209-351 Sentence denotes Cut surface showed consolidation of lobes and red congested areas, with thickening of the interstitial septa and pulmonary edema (Figure 1A1).
T113 352-404 Sentence denotes Subsegmental pulmonary embolism was seen in 5 cases.
T114 405-414 Sentence denotes Figure 1.
T115 416-446 Sentence denotes Pathological findings in lung.
T116 447-526 Sentence denotes A1, Lungs showed an increase in volume and were firmer and heavier than normal.
T117 527-719 Sentence denotes A2 and A3, Light microscopic analysis shows parenchymal multifocal damage with intraalveolar inflammation, fibrin, and hyaline membranes consistent with a diagnosis of diffuse alveolar damage.
T118 720-805 Sentence denotes Both acute exudative inflammatory process and fibrous proliferative phase were found.
T119 806-949 Sentence denotes A3 and A4, Hyperplasia of type II pneumocyte, characterized by amphophilic cytoplasm, large nuclei, and prominent nucleoli, are shown (arrows).
T120 950-977 Sentence denotes B1, Alveolar duct fibrosis.
T121 978-1012 Sentence denotes B2, Fibrin thrombi in capillaries.
T122 1013-1080 Sentence denotes B3, Vascular injury including vessel vasculitis and vascular edema.
T123 1081-1102 Sentence denotes B4, Pleural fibrosis.
T124 1103-1145 Sentence denotes Abbreviation: H&E, haematoxylin and eosin.
T125 1146-1192 Sentence denotes Scale bars: A2, 14 µm; A3–B3, 7 µm; B4, 21 µm.
T126 1194-1215 Sentence denotes Microscopic Findings.
T127 1216-1278 Sentence denotes A range of common lung findings were seen on light microscopy.
T128 1279-1492 Sentence denotes Parenchymal multifocal damage with intraalveolar exudative and proliferative inflammation (Figure 1A2), with fibrin, hyaline membranes (Figure 1A3) consistent with a diagnosis of diffuse alveolar damage (Table 3).
T129 1493-1698 Sentence denotes Organizing pneumonia with fibrosis and type II pneumocyte hyperplasia, amphophilic cytoplasm, large nuclei, and prominent nucleoli, were indicative of cytopathic virus-induced changes (Figure 1A3 and 1A4).
T130 1699-1843 Sentence denotes Fibroblastic foci consisting of loose organizing connective tissue reflective of alveolar duct fibrosis were seen (fibrotic phase) (Figure 1B1).
T131 1844-1971 Sentence denotes Other findings included: pleural fibrosis (Figure 1B4), vascular injury with thrombi (Figure 1B2), and vasculitis (Figure 1B3).
T132 1972-2280 Sentence denotes A main feature was the presence of numerous inflammatory cells consisting of granulocytes (CD15+) (Supplementary Figure 1A1 and 1A2), macrophages (CD68+) (Supplementary Figure 1A3 and 1A4), and T lymphocytes (CD3+) infiltrating into alveolar septa and clustering around capillary vessels (Supplementary 1B1).
T133 2281-2393 Sentence denotes Immunohistochemistry showed the presence of both CD4+ and CD8+ T lymphocytes (Supplementary Figure 1B2 and 1B3).
T134 2394-2478 Sentence denotes Of note, lymphocytes were CD20− indicating an absence of infiltrating B lymphocytes.
T135 2479-2629 Sentence denotes Thrombi were present and immunohistochemistry showed the presence of platelet aggregates and megakaryocytes within thrombi (Supplementary Figure 1B4).
T136 2630-2638 Sentence denotes Table 3.
T137 2640-2663 Sentence denotes Histopathology Findings
T138 2664-2725 Sentence denotes Findings Group 1, No. (%) (n = 18) Group 2, No. (%) (n = 4)
T139 2726-2730 Sentence denotes Lung
T140 2731-2769 Sentence denotes  Hyaline membranes 8 (44.4) 2 (50.0)
T141 2770-2824 Sentence denotes  Hyperplasia of type II pneumocyte 11 (61.2) 4 (100)
T142 2825-2858 Sentence denotes  Alveolar plug 8 (44.4) 4 (100)
T143 2859-2903 Sentence denotes  Alveolar fibrin deposit 9 (50.0) 3 (75.0)
T144 2904-2936 Sentence denotes  Hemorrhage 10 (55.6) 2 (50.0)
T145 2937-2976 Sentence denotes  Inflammatory cells 13 (72.3) 4 (100)
T146 2977-3038 Sentence denotes  Diffuse alveolar damage, fibrotic phase 12 (66.7) 1 (25.0)
T147 3039-3073 Sentence denotes  Microthrombi 14 (77.8) 2 (50.0)
T148 3074-3104 Sentence denotes  Vasculitis 8 (44.4) 4 (100)
T149 3105-3152 Sentence denotes  Multinucleated giant cells 4 (22.3) 2 (50.0)
T150 3153-3160 Sentence denotes Cardiac
T151 3161-3193 Sentence denotes  Myocarditis 9 (50.0) 3 (75.0)
T152 3194-3225 Sentence denotes  Vasculitis 5 (27.8) 3 (75.0)
T153 3226-3271 Sentence denotes  Inflammatory infiltrate 13 (72.3) 3 (75.0)
T154 3272-3307 Sentence denotes  Focal necrosis 6 (33.4) 2 (50.0)
T155 3308-3340 Sentence denotes  Pericarditis 9 (50.0) 4 (100)
T156 3341-3379 Sentence denotes  Vascular fibrosis 4 (22.3) 2 (50.0)
T157 3380-3387 Sentence denotes Hepatic
T158 3388-3432 Sentence denotes  Inflammatory infiltrate 8 (44.4) 3 (75.0)
T159 3433-3464 Sentence denotes  Congestion 8 (44.4) 2 (50.0)
T160 3465-3495 Sentence denotes  Steatosis 9 (50.0) 3 (75.0)
T161 3496-3501 Sentence denotes Renal
T162 3502-3546 Sentence denotes  Inflammatory infiltrate 9 (50.0) 3 (75.0)
T163 3547-3586 Sentence denotes  Glomerulosclerosis 9 (50.0) 3 (75.0)
T164 3587-3628 Sentence denotes  Interstitial fibrosis 9 (50.0) 4 (100)
T165 3629-3636 Sentence denotes Splenic
T166 3637-3676 Sentence denotes  Congested red pulp 15 (83.4) 4 (100)
T167 3677-3717 Sentence denotes  Lymphoid hypoplasia 11 (61.2) 4 (100)
T168 3718-3729 Sentence denotes Bone marrow
T169 3730-3770 Sentence denotes  Megakaryocytes hyperplasia 0 2 (50.0)
T170 3771-3802 Sentence denotes  Adipocytes 7 (38.9) 1 (25.0)
T171 3804-3834 Sentence denotes Immunohistochemistry Findings.
T172 3835-4019 Sentence denotes T-cell activation is modulated by dipeptidyl peptidase-4 (DPP4) [16] and thus the expression of CD26/DPP4 and CXCR3/CD183 was analyzed on lung tissues from group 2 patients (Figure 2).
T173 4020-4158 Sentence denotes Numerous CD26+ cells were found in the alveolar septa (Figure 2A1–2A3) with intense staining seen in the type II pneumocytes (Figure 2A3).
T174 4159-4256 Sentence denotes Positive cells entrapped with fibrin clots in the vascular lumen were also observed (Figure 2A4).
T175 4257-4448 Sentence denotes CXCR3 immunostaining showed lymphocytes localized in inflammatory perivascular aggregates (Figure 2B1, 2B2, and 2B4) which spread into alveolar septa and alveolar spaces (Figure 2B2 and 2B3).
T176 4449-4458 Sentence denotes Figure 2.
T177 4460-4511 Sentence denotes Immunohistological characterization of lung tissue.
T178 4512-4573 Sentence denotes A1–A4, CD26/dipeptidyl peptidase-4 expression in lung tissue.
T179 4574-4644 Sentence denotes Numerous strongly positive CD26+ cells are seen in the alveolar septa.
T180 4645-4710 Sentence denotes A3, Intense staining is seen in the type II pneumocytes (arrows).
T181 4711-4788 Sentence denotes A4, Positive cells are also seen entrapped with fibrin in the vascular lumen.
T182 4789-4966 Sentence denotes B1–B4, CXCR3/CD183 immunostaining shows intense staining of lymphocytes localized in the inflammatory perivascular aggregates and spread into alveolar septa and alveolar spaces.
T183 4967-5042 Sentence denotes Scale bars: A1 and B1, 100 µm; A2, A3, and B4, 7 µm; A4, B2, and B3, 14 µm.
T184 5044-5074 Sentence denotes Electron Microscopic Findings.
T185 5075-5229 Sentence denotes SARS-CoV-2 particles were detected within type II pneumocytes, which showed degenerating features characterized by fine and uniformly dispersed chromatin.
T186 5230-5340 Sentence denotes These pneumocytes displayed swollen mitochondrial profiles and dilated rough endoplasmic reticulum (Figure 3).
T187 5341-5454 Sentence denotes Numerous virus-containing compartments (VCC) of different sizes and shapes were detected (Figure 3A, 3B, and 3D).
T188 5455-5574 Sentence denotes Interestingly, spherules, very small vesicles containing single viral particles (Figure 3B and 3C), were also observed.
T189 5575-5584 Sentence denotes Figure 3.
T190 5586-5658 Sentence denotes SARS-CoV-2 detection in lung tissue by transmission electron microscopy.
T191 5659-5760 Sentence denotes A, SARS-CoV-2 particles are visible in virus-containing compartments in type II pneumocytes (arrows).
T192 5761-5840 Sentence denotes B–D, Numerous viral particles are enclosed in single-membrane vacuoles (arrow).
T193 5841-5912 Sentence denotes Other, very small vesicles contain single viral particles (arrowheads).
T194 5913-5945 Sentence denotes Scale bars: A, 1 µm; B–D, 200nm.
T195 5947-5961 Sentence denotes Heart Findings
T196 5963-5984 Sentence denotes Macroscopic Findings.
T197 5985-6129 Sentence denotes The hearts in all group 1 and 2 patients showed increased size and weight, hypertrophy, and dilation of the left and right atria and ventricles.
T198 6130-6239 Sentence denotes The myocardium appeared pale and flabby, and endocardium showed punctuate petechial hemorrhages (Figure 4A1).
T199 6240-6329 Sentence denotes Some patients in group 1 had pathological changes that were related to the patient’s age.
T200 6330-6522 Sentence denotes These included myocardial ischemic or inflammatory changes, hypertensive changes of the left ventricular cavity, and valvular calcification of the mitral annulus and aortic valve (Figure 4A2).
T201 6523-6532 Sentence denotes Figure 4.
T202 6534-6564 Sentence denotes Histological changes in heart.
T203 6565-6610 Sentence denotes A1, Hearts were increased in size and weight.
T204 6611-6651 Sentence denotes The myocardium appeared pale and flabby.
T205 6652-6703 Sentence denotes Endocardium showed punctuate petechial hemorrhages.
T206 6704-6929 Sentence denotes A2, Age-related disease of the heart was represented by volume changes of the left ventricular cavity and exacerbated by systemic hypertension with valve changes including calcification of the mitral annulus and aortic valve.
T207 6930-7088 Sentence denotes A3 and A4, Heart tissue shows myocytes hypertrophy, and variable degrees of interstitial and vascular fibrosis with mononuclear cells infiltrating adventitia.
T208 7089-7229 Sentence denotes B1, Active myocarditis was characterized by mononuclear, predominantly lymphocytic infiltrate, associated with focal myocytes necrosis (B2).
T209 7230-7300 Sentence denotes B3, Fibrinous, hemorrhagic areas with myofibers disarray were present.
T210 7301-7404 Sentence denotes B4, Pericarditis with lymphocytic infiltration and increase in fibrous tissue was seen in all patients.
T211 7405-7447 Sentence denotes Abbreviation: H&E, haematoxylin and eosin.
T212 7448-7500 Sentence denotes Scale bars: A3 and B4, 21 µm; A4–B2,7 µm; B3, 14 µm.
T213 7502-7523 Sentence denotes Microscopic Findings.
T214 7524-7658 Sentence denotes Microscopic changes seen were hypertrophy of myocytes and variable degrees of interstitial and vascular fibrosis (Figure 4A3 and 4A4).
T215 7659-7758 Sentence denotes Mononuclear cells infiltrating adventitia was found predominantly in group 2 patients (Figure 4A4).
T216 7759-7992 Sentence denotes Active myocarditis (Figure 4B1) characterized by mononuclear, predominantly lymphocytic, infiltrate, and was associated with focal myocytes necrosis (Figure 4B2), fibrinous, and hemorrhagic areas with myofibers disarray (Figure 4B3).
T217 7993-8078 Sentence denotes Pericarditis (fibrinous or fibrous) was seen mainly in group 2 patients (Figure 4B4).
T218 8080-8127 Sentence denotes Liver, Kidney, Spleen, and Bone Marrow Findings
T219 8129-8135 Sentence denotes Liver.
T220 8136-8217 Sentence denotes Macroscopic inspection of the liver of all patients showed parenchyma congestion.
T221 8218-8504 Sentence denotes The main findings at histological level were sinusoidal congestion and extravasation of red blood cells into the space of Disse (Figure 5A1) and in a few cases this was associated with congestion of small veins and hepatocyte necrosis (Figure 5A2 and 5A3) and infiltration (Figure 5A4).
T222 8505-8623 Sentence denotes Macrovacuolar and microvacuolar steatosis was seen mostly in group 2 patients (Figure 5A1, 5A2, and 5A4, and Table 3).
T223 8624-8633 Sentence denotes Figure 5.
T224 8635-8677 Sentence denotes Pathological findings in liver and kidney.
T225 8678-8784 Sentence denotes A1, Liver tissue shows sinusoidal congestion and extravasation of red blood cells into the space of Disse.
T226 8785-8867 Sentence denotes In some cases, small vein congestion (A2) and hepatic necrosis (A3) were reported.
T227 8868-8911 Sentence denotes A4, Inflammatory infiltration was observed.
T228 8912-9009 Sentence denotes A1, A2, and A4, Macrovacuolar and microvacuolar steatosis were observed in the majority of cases.
T229 9010-9063 Sentence denotes B1, Kidney glomerular endothelial cells were swollen.
T230 9064-9124 Sentence denotes B2, Fibrin deposit is visible underneath the Bowman capsule.
T231 9125-9205 Sentence denotes B3, Tubulointerstitial inflammation and (B4) glomerular sclerosis were observed.
T232 9206-9248 Sentence denotes Abbreviation: H&E, haematoxylin and eosin.
T233 9249-9304 Sentence denotes Scale bars: A1–A4, and B3, 50 µm; B1, B2, and B4, 14 µm
T234 9306-9313 Sentence denotes Kidney.
T235 9314-9398 Sentence denotes The kidneys of all patients generally had normal shape with reduced volume and size.
T236 9399-9441 Sentence denotes Outer surfaces showed reddish depressions.
T237 9442-9580 Sentence denotes Histological examination showed interstitial fibrosis, mainly in group 2 patients (Figure 5B1), with swollen glomerular endothelial cells.
T238 9581-9653 Sentence denotes Fibrin deposits were visible underneath the Bowman capsule (Figure 5B2).
T239 9654-9833 Sentence denotes Chronic tubular-interstitial inflammation (Figure 5B3) and glomerular sclerosis were observed (Figure 5B4) even in patients without a history of previous kidney disease (Table 3).
T240 9835-9842 Sentence denotes Spleen.
T241 9843-9916 Sentence denotes The spleens of all patients had normal shape but reduced volume and size.
T242 9917-10057 Sentence denotes The splenic white pulps of all 4 of the group 2 cases showed lymphoid hypoplasia with congested red pulp (Figure 6A1 and 6A2), and Table 3).
T243 10058-10067 Sentence denotes Figure 6.
T244 10069-10105 Sentence denotes Histology of spleen and bone marrow.
T245 10106-10174 Sentence denotes A1 and A2, Lymphoid hypoplasia is visible in the splenic white pulp.
T246 10175-10291 Sentence denotes B1 and B2, Bone marrows tissue shows replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow.
T247 10292-10339 Sentence denotes Megakaryocyte hyperplasia is observed (arrows).
T248 10340-10382 Sentence denotes Abbreviation: H&E, haematoxylin and eosin.
T249 10383-10441 Sentence denotes C1, Macrophages (CD68+) are present in bone marrow tissue.
T250 10442-10506 Sentence denotes C2, CD68+ cells displaying features of hemophagocytosis (arrow).
T251 10507-10551 Sentence denotes Scale bars: A1, A2, B2–C2, 7 µm; B1, 100 µm.
T252 10553-10565 Sentence denotes Bone Marrow.
T253 10566-10736 Sentence denotes Microscopic analysis of the bone marrows generally showed replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow in group 1 patients (Figure 6B1).
T254 10737-10821 Sentence denotes Megakaryocytes hyperplasia (Figure 6B2) was seen in 2 patients of group 2 (Table 3).
T255 10822-10930 Sentence denotes Numerous macrophages (CD68+) were seen and they displayed features of hemophagocytosis (Figure 6C1 and 6C2).