Id |
Subject |
Object |
Predicate |
Lexical cue |
T5 |
0-44 |
Sentence |
denotes |
SARS‐CoV‐2 causes serious disease in humans. |
T6 |
45-131 |
Sentence |
denotes |
First identified in November/December 2019 in China, it has rapidly spread world‐wide. |
T7 |
132-310 |
Sentence |
denotes |
We analyzed 2790 SARS‐CoV‐2 genome sequences from 56 countries that were available on April 2, 2020 to assess the evolution of the virus during this early phase of its expansion. |
T8 |
311-425 |
Sentence |
denotes |
We aimed to assess sequence variations that had evolved in virus genomes, giving greatest attention to the S gene. |
T9 |
426-553 |
Sentence |
denotes |
We also aimed to identify haplotypes that the variations may define and consider their geographic and chronologic distribution. |
T10 |
554-643 |
Sentence |
denotes |
Variations at 1930 positions that together cause 1203 amino acid changes were identified. |
T11 |
644-777 |
Sentence |
denotes |
The frequencies of changes normalized to lengths of genes and encoded proteins were relatively high in ORF3a and relatively low in M. |
T12 |
778-982 |
Sentence |
denotes |
A variation that causes an Asp614Gly near the receptor binding domain of S was found at high frequencies, and it was considered that this may contribute to the rapid spread of viruses with this variation. |
T13 |
983-1032 |
Sentence |
denotes |
Our most important findings relate to haplotypes. |
T14 |
1033-1201 |
Sentence |
denotes |
Sixty‐six haplotypes that constitute thirteen haplotype groups (H1‐H13) were identified, and 84.6% of the 2790 sequences analyzed were associated with these haplotypes. |
T15 |
1202-1284 |
Sentence |
denotes |
The majority of the sequences (75.1%) were associated with haplotype groups H1‐H3. |
T16 |
1285-1373 |
Sentence |
denotes |
The distribution pattern of the haplotype groups differed in various geographic regions. |
T17 |
1374-1412 |
Sentence |
denotes |
A few were country/territory specific. |
T18 |
1413-1477 |
Sentence |
denotes |
Location and time of emergence of some haplotypes are discussed. |
T19 |
1478-1613 |
Sentence |
denotes |
Importantly, nucleotide variations that define the various haplotypes and Tag/signature variations for most of haplotypes are reported. |
T20 |
1614-1675 |
Sentence |
denotes |
The practical applications of these variations are discussed. |