PMC:7537300 / 166-1841 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5 0-44 Sentence denotes SARS‐CoV‐2 causes serious disease in humans.
T6 45-131 Sentence denotes First identified in November/December 2019 in China, it has rapidly spread world‐wide.
T7 132-310 Sentence denotes We analyzed 2790 SARS‐CoV‐2 genome sequences from 56 countries that were available on April 2, 2020 to assess the evolution of the virus during this early phase of its expansion.
T8 311-425 Sentence denotes We aimed to assess sequence variations that had evolved in virus genomes, giving greatest attention to the S gene.
T9 426-553 Sentence denotes We also aimed to identify haplotypes that the variations may define and consider their geographic and chronologic distribution.
T10 554-643 Sentence denotes Variations at 1930 positions that together cause 1203 amino acid changes were identified.
T11 644-777 Sentence denotes The frequencies of changes normalized to lengths of genes and encoded proteins were relatively high in ORF3a and relatively low in M.
T12 778-982 Sentence denotes A variation that causes an Asp614Gly near the receptor binding domain of S was found at high frequencies, and it was considered that this may contribute to the rapid spread of viruses with this variation.
T13 983-1032 Sentence denotes Our most important findings relate to haplotypes.
T14 1033-1201 Sentence denotes Sixty‐six haplotypes that constitute thirteen haplotype groups (H1‐H13) were identified, and 84.6% of the 2790 sequences analyzed were associated with these haplotypes.
T15 1202-1284 Sentence denotes The majority of the sequences (75.1%) were associated with haplotype groups H1‐H3.
T16 1285-1373 Sentence denotes The distribution pattern of the haplotype groups differed in various geographic regions.
T17 1374-1412 Sentence denotes A few were country/territory specific.
T18 1413-1477 Sentence denotes Location and time of emergence of some haplotypes are discussed.
T19 1478-1613 Sentence denotes Importantly, nucleotide variations that define the various haplotypes and Tag/signature variations for most of haplotypes are reported.
T20 1614-1675 Sentence denotes The practical applications of these variations are discussed.