| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T616 |
0-176 |
Sentence |
denotes |
In contrast, the immunosuppressive effects of EPA and DHA supplementation can decrease the immune response against viral infections and thus compromising removal from the body. |
| T617 |
177-356 |
Sentence |
denotes |
C57BL/6J mice supplemented with fish oil and infected with H1N1 influenza virus showed a 40% higher mortality rate and 70% higher viral load compared to the corresponding control. |
| T618 |
357-557 |
Sentence |
denotes |
Moreover, the treated mice had markedly reduced numbers of CD8+ T lymphocytes and reduced mRNA expression of inflammatory mediators IL-6 and TNF-α (Schwerbrock, Karlsson, Shi, Sheridan, & Beck, 2009). |
| T619 |
558-818 |
Sentence |
denotes |
Similarly, BALB/c mice fed a high-fat diet rich in EPA and DHA had reduced levels of IFN-γ, serum immunoglobulin G and lung immunoglobulin A-specific antibodies following infection with the influenza virus, indicating a virus-specific lung T cell cytotoxicity. |
| T620 |
819-948 |
Sentence |
denotes |
These results suggested supplementation with a diet rich in EPA and DHA could impair immune response by delaying virus clearance. |
| T621 |
949-1278 |
Sentence |
denotes |
However, differences noticed during the course of infection did not affect the ultimate outcome as n-3 PUFA-fed mice were finally able to clear the virus and returned to pre-infection food consumption and body weight similar to the control group (Byleveld, Pang, Clancy, & Roberts, 1999; Byleveld, Pang, Clancy, & Roberts, 2000). |
| T622 |
1279-1467 |
Sentence |
denotes |
Importantly, other factors contribute to these opposite results, for example, an initial weight loss is typically observed when mice are supplemented with fish oil (Byleveld et al., 1999). |
| T623 |
1468-1632 |
Sentence |
denotes |
In addition, thoroughly controlled animal studies have not been conducted with the SARS-CoV-2 virus and significant variations between viruses should be considered. |
| T624 |
1633-1784 |
Sentence |
denotes |
Therefore, further research is needed to understand the role of EPA and DHA in the immune response related specifically to SARS-CoV-2 viral infections. |
