LitCovid-sentences  

PMC:7534795 / 8038-12622 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T45 0-44 Sentence denotes 2 COVID-19 and cardiovascular complications
T46 45-277 Sentence denotes The correlation between pneumonia, an inflammatory condition of lung alveoli with a compromised ability for gas exchange, and cardiovascular complications has been well established (Cilli et al., 2018; Corrales-Medina et al., 2011).
T47 278-560 Sentence denotes For example, patients with underlying cardiovascular disease are more likely to develop community-acquired pneumonia (Corrales-Medina et al., 2015) and about 8 to 25% of patients with community acquired pneumonia develop at least one cardiac complication during their hospital stay.
T48 561-715 Sentence denotes The exaggerated cardiovascular episodes after pneumonia have been associated with increased mortality (Corrales-Medina et al., 2012; Viasus et al., 2013).
T49 716-907 Sentence denotes In line with these observations, cardiac complications have been reported in patients with novel coronavirus infections such as tachycardia and hypotension, which are common in SARS patients.
T50 908-1040 Sentence denotes Moreover, arrhythmia, cardiomegaly and diastolic dysfunction have been reported in SARS patients (Li et al., 2003; Yu et al., 2006).
T51 1041-1192 Sentence denotes In addition, infection with MERS-CoV was associated with acute myocarditis, myocardial edema and severe left ventricular dysfunction (Alhogbani, 2016).
T52 1193-1367 Sentence denotes In the context of COVID-19, both patients with and without underlying cardiovascular comorbidities can develop cardiovascular complications secondary to SARS-CoV-2 infection.
T53 1368-1731 Sentence denotes For example, Wang et al., reported that among 138 hospitalized patients with COVID-19 in Wuhan, China, cardiac injury, as evidenced by new ECG or echocardiographic abnormalities or elevated high-sensitivity cardiac troponin I, was present in 7.2% of all patients and 22% of patients who required intensive care unit (ICU) hospitalization (Wang, Hu, et al., 2020).
T54 1732-2074 Sentence denotes Moreover, the National Health Commission of China reported that 12% of patients infected with SARS-CoV-2 and without known cardiovascular disease (CVD) had elevated troponin levels or cardiac arrest during hospitalization, 17% had coronary heart disease and 35% of patients had hypertension (Zheng, Ma, Zhang, & Xie, 2020; Zhou et al., 2020).
T55 2075-2258 Sentence denotes However, there is accumulating evidence that COVID-19 patients with underlying CVD are at higher risk for developing severe complications (Huang et al., 2020; Wang, Hu, et al., 2020).
T56 2259-2466 Sentence denotes For instance, older patients with underlying CVD who are infected with SARS-CoV-2 are more prone to become severely ill, develop cardiac injury or require intensive care (Guo et al., 2020; Shi et al., 2020).
T57 2467-2696 Sentence denotes The death rate among patients with underlying CVD has been stated as 10.5%, which is much higher than that of the general population (Epidemiology Working Group for Ncip Epidemic Response & Prevention, 2020; Wu & McGoogan, 2020).
T58 2697-2930 Sentence denotes Furthermore, according to an epidemiological study conducted in China, 4.2% of the confirmed cases and 22.7% of mortalities have cardiovascular comorbidities (Epidemiology Working Group for Ncip Epidemic Response & Prevention, 2020).
T59 2931-3156 Sentence denotes Many COVID-19 patients suffer from persistent hypotension, myocardial injury, myocarditis, left ventricular dysfunction, arrhythmia and HF (Guan, et al., 2020; Guo et al., 2020; Inciardi et al., 2020; Zhou, Yu, et al., 2020).
T60 3157-3393 Sentence denotes Importantly, cardiac biopsy samples collected from patients with COVID-19 demonstrated increased interstitial infiltration of mononuclear inflammatory cells providing extra evidence of myocarditis in COVID-19 patients (Xu et al., 2020).
T61 3394-3685 Sentence denotes Therefore, cardiovascular damage secondary to COVID-19 is now drawing growing attention in clinical practice (Table 2 ) and the American College of Cardiology recently issued a clinical report to address the cardiovascular consequences of SARS-CoV-2 infection (Mohammad Madjid et al., 2020).
T62 3686-3755 Sentence denotes Table 2 Overview of COVID-19-associated cardiovascular complications.
T63 3756-3823 Sentence denotes COVID-19-induced cardiovascular injury Proposed mechanism of injury
T64 3824-3870 Sentence denotes • Acute myocarditis • Direct pathogen invasion
T65 3871-3896 Sentence denotes • Indirect cytokine storm
T66 3897-3946 Sentence denotes • Instability of coronary atherosclerotic plaques
T67 3947-3961 Sentence denotes • Coagulopathy
T68 3962-3972 Sentence denotes • Acute MI
T69 3973-3987 Sentence denotes • Hypertension
T70 3988-4044 Sentence denotes • Left ventricular dilation, hypertrophy and dysfunction
T71 4045-4147 Sentence denotes • Arrhythmias (long QT-syndrome, torsade de pointes) • Indirect inflammatory response (Cytokine storm)
T72 4148-4226 Sentence denotes • Worsening of heart failure • Indirect inflammatory response (Cytokine storm)
T73 4227-4288 Sentence denotes • Volume overload due to impaired sodium and water metabolism
T74 4289-4326 Sentence denotes • Disturbance of endothelial function
T75 4327-4369 Sentence denotes • Pyroptosis of cardiomyocytes • Hypoxemia
T76 4370-4408 Sentence denotes • Activation of the NLRP3 inflammasome
T77 4409-4584 Sentence denotes • Severe tachycardia, increased peripheral resistance, hypertension, increased myocardial oxygen requirements and ischemia • Pneumonia-induced increase in sympathetic activity