| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T84 |
73-198 |
Sentence |
denotes |
SARS-Cov-2 may be taken up by cardiac cells using different routes, such as via ACE2 receptors expressed on the cell surface. |
| T85 |
199-421 |
Sentence |
denotes |
Following entry, SARS-CoV-2 may exert cardiac injury by direct action and/or induction of immune responses resulting in release of pro-inflammatory cytokines (‘Cytokine storm’) such as IL, TNF-α, INF-γ, FGF, MCP1 and VEGF. |
| T86 |
422-660 |
Sentence |
denotes |
SARS-CoV-2 can trigger the innate immune response involving NLRP3 inflammasomes which lead to activation of pro-inflammatory cytokines, IL-1β and IL-18 and the inflammatory cascade (IL-6 and TNF-α) resulting in tissue damage and fibrosis. |
| T87 |
661-848 |
Sentence |
denotes |
SARS-CoV-2-induced pneumonia results in the development of hypoxemia which can impair Ca2+ homeostasis, increase ROS production and activate NLRP3 inflammasomes leading to cardiac damage. |
| T88 |
849-993 |
Sentence |
denotes |
Activation of the sympathetic nervous system in response to pneumonia leads to vasoconstriction and tachycardia compromising coronary perfusion. |
| T89 |
994-1079 |
Sentence |
denotes |
This results in a mismatch of myocardial O2 demand and supply precipitating ischemia. |
| T90 |
1080-1217 |
Sentence |
denotes |
SARS-CoV-2 can destabilize coronary atherosclerotic plaques and mediate platelet aggregation resulting in arterial and venous thrombosis. |
| T91 |
1218-1322 |
Sentence |
denotes |
Altogether, these SARS-CoV-2 mediated effects may be contributing to the observed cardiovascular injury. |
| T92 |
1323-1786 |
Sentence |
denotes |
ACE2, Angiotensin-converting enzyme-2; Ca2+, Calcium; FGF, Fibroblast growth factor; IL, Interleukin; INF, Interferon; MCP-1, Monocyte chemoattractant protein-1; NFκB, Nuclear factor kappa-light-chain enhancer activated B-cells; NLRP3, NACHT, LRR and PYD domains-containing protein 3; O2, Oxygen; ROS, Reactive oxygen species; SARS-CoV-2, Severe and acute respiratory syndrome coronavirus; TNF-α, Tumor necrosis factor-α; VEGF, Vascular endothelial growth factor. |
