LitCovid-sentences  

PMC:7532482 / 21349-23571 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T180 0-70 Sentence denotes Gene-pathway network was constructed to the core and key target genes.
T181 71-145 Sentence denotes The network showed that RELA had largest degree, was the core target gene.
T182 146-241 Sentence denotes Other top five genes such as MAPK1, MAPK14, CASP3, CASP8 and IL6 might be the key target genes.
T183 242-425 Sentence denotes The pathophysiological process of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) infection is similar to that of SARS-CoV infection, with a strong inflammatory response.
T184 426-756 Sentence denotes The SARS-COV-2 virus mainly targets respiratory epithelial cells, alveolar epithelial cells, vascular endothelial cells and pulmonary macrophages, all of which express Angiotensin converting enzyme 2 (ACE2) receptor, triggering the generation of pro- inflammatory cytokines and chemokines (including IL-6, TNF, IL-10 and MCP1) 41.
T185 757-959 Sentence denotes The NF-kB family member RELA is a widely expressed and effective transcriptional activator that activates the expression of many inflammatory through exposure to pathogens and inflammatory cytokines 42.
T186 960-1021 Sentence denotes RELA may play an important role in the infection of COVID-19.
T187 1022-1229 Sentence denotes MAPK1 and MAPK14 are members of the MAPK family, which can regulate multiple cellular processes, such as response to oxidative stress, anti-inflammatory, immune response, apoptosis and cell proliferation 43.
T188 1230-1466 Sentence denotes Joseph et al showed SASR-CoV-2 could induce severe inflammation by directly activating p38 MAPK pathway and many p38 MAPK inhibitors are in the clinical stage and should be considered for clinical trial for severe COVID-19 infection 44.
T189 1467-1672 Sentence denotes CASP3 and CASP8, a family of cysteine-dependent proteases, play an important role in these events through activation of other apoptotic proteins mediated by proteolysis and cleavage of nuclear proteins 45.
T190 1673-1805 Sentence denotes In Krahling's study, infection of 293/ACE2 cells with SARS-CoV activated apoptosis-associated events, such as caspase3, caspase 846.
T191 1806-1940 Sentence denotes Therefore, we conclude that CASP3 and CASP8 may be activated and play an important role in the pathophysiological process of COVID-19.
T192 1941-2011 Sentence denotes Higher plasma level of IL-6 was found in ICU patients with COVID-1947.
T193 2012-2222 Sentence denotes Tocilizumab, a recombinant humanized anti-human IL-6 receptor monoclonal antibody, improved the clinical outcome in 20 severe and critical COVID-19 patients and is an effective treatment to reduce mortality 48.