LitCovid-sentences  

PMC:7532482 / 17209-24609 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T146 0-10 Sentence denotes Discussion
T147 11-91 Sentence denotes The theory of TCM has been formed and developed for thousands of years in China.
T148 92-216 Sentence denotes In China, TCM has a good therapeutic effect on COVID-19, which has been written into the diagnosis and treatment guidelines.
T149 217-358 Sentence denotes The guideline points out that the combination of traditional Chinese and western medicine should be strengthened in the treatment process 34.
T150 359-515 Sentence denotes SFJDC is a traditional Chinese medicine, mainly used to treat upper respiratory tract infections, such as influenza, sore throat, mumps, streptococcus, etc.
T151 516-519 Sentence denotes 21.
T152 520-593 Sentence denotes Now, SFJDC has become an effective drug for the treatment of COVID-19 35.
T153 594-728 Sentence denotes In recent years, the research on Chinese medicine prescriptions has developed to the level of effective parts, components, components.
T154 729-856 Sentence denotes Network pharmacology can better understand and demonstrate the interaction between multi-component multi-target and disease 36.
T155 857-997 Sentence denotes This study aims to analyze the active components and potential mechanism of SFJDC in the treatment of COVID-19 through network pharmacology.
T156 998-1115 Sentence denotes In the present study, the ingredients-targets network of SFJDC was constructed using 110 ingredients and 120 targets.
T157 1116-1216 Sentence denotes The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction.
T158 1217-1400 Sentence denotes The results showed that most compounds of SFJDC were affected by multiple target genes, such as Wogonin, licochalcone a and acacetin acted on 42, 30 and 23 target genes, respectively.
T159 1401-1473 Sentence denotes Various compounds of SFJDC may have the same targets to achieve synergy.
T160 1474-1640 Sentence denotes Wogonin, a naturally occurring flavonoid, has been shown to multi-activity, such as anti-inflammatory, anti-fibrosis, anti-cancer and chondroprotective properties 37.
T161 1641-1731 Sentence denotes Study showed that wogonin had an anti-infulenza activity by modulation of AMPK pathway 38.
T162 1732-1889 Sentence denotes Licochalcone a, a flavonoid extracted from licorice toot, was known for its anti-inflammatory, anti-cancer, anti-oxidative and anti-bacterial bioactivity 39.
T163 1890-1991 Sentence denotes Acacetin, a flavone compound, played an important role in anti-inflammatory and anti-peroxidative 40.
T164 1992-2067 Sentence denotes In addition, they have high OB and acacetin from 2 herbs (PR, IR) of SFJDC.
T165 2068-2173 Sentence denotes The three main ingredients were anti-inflammatory and COVID-19 caused by a series of inflammatory storms.
T166 2174-2258 Sentence denotes Hence, they might be the crucial effective compounds of SFJDC according the network.
T167 2259-2370 Sentence denotes PPI network of SFJDC against NCP were visualized using Cytoscape software to obtain the candidate target genes.
T168 2371-2504 Sentence denotes In order to obtain the more accurate genes, two parameters including DC and BC were used to screen nodes and structure a new network.
T169 2505-2616 Sentence denotes 169 genes were eventually identified for SFJDC against NCP including 156 other human genes and 13 target genes.
T170 2617-2701 Sentence denotes Twenty-three candidate genes (CGs) were identified by using the VennDiagram package.
T171 2702-2760 Sentence denotes CGs were enriched in BP, CC, MF by GO enrichment analysis.
T172 2761-2952 Sentence denotes Based on GO terms data, we found that some terms were response to lipopolysaccharide or bacterial origin, membrane raft, membrane microdomain, BH domain binding and cytokine receptor binding.
T173 2953-3156 Sentence denotes COVID-19 infections leaded to a strong immune response and inflammatory storm in which a large number of cytokines were activated, so SFJDC might regulate COVID-19 through the above biological processes.
T174 3157-3236 Sentence denotes SFJDC, as a TCM formula, has multi-component, multi-target-gene, multi-pathway.
T175 3237-3305 Sentence denotes In the present study, 110 KEGG pathways were significantly enriched.
T176 3306-3679 Sentence denotes Seven of the top 20 pathways were associated with viral infection including Kaposi sarcoma-associated herpesvirus infection, Human cytomegalovirus infection, Hepatitis B, Influenza A, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection and Measles, and three were associated with lung disease contained tuberculosis, pertussis and small cell lung cancer.
T177 3680-3866 Sentence denotes Multiple targets of SFJDC may also inhibit the activation of cytokines and reduce inflammation by regulating cytokine pathways, such as IL-17 signaling pathway and TNF signaling pathway.
T178 3867-3942 Sentence denotes In this study, we obtained 20 functional annotation clusters through DAVID.
T179 3943-4139 Sentence denotes Annotation Cluster1 including Asthma, Bronchiolitis Viral, Respiratory Syncytial Virus Infections, respiratory syncytial virus bronchiolitis were lung related diseases and Virus infection disease.
T180 4140-4210 Sentence denotes Gene-pathway network was constructed to the core and key target genes.
T181 4211-4285 Sentence denotes The network showed that RELA had largest degree, was the core target gene.
T182 4286-4381 Sentence denotes Other top five genes such as MAPK1, MAPK14, CASP3, CASP8 and IL6 might be the key target genes.
T183 4382-4565 Sentence denotes The pathophysiological process of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) infection is similar to that of SARS-CoV infection, with a strong inflammatory response.
T184 4566-4896 Sentence denotes The SARS-COV-2 virus mainly targets respiratory epithelial cells, alveolar epithelial cells, vascular endothelial cells and pulmonary macrophages, all of which express Angiotensin converting enzyme 2 (ACE2) receptor, triggering the generation of pro- inflammatory cytokines and chemokines (including IL-6, TNF, IL-10 and MCP1) 41.
T185 4897-5099 Sentence denotes The NF-kB family member RELA is a widely expressed and effective transcriptional activator that activates the expression of many inflammatory through exposure to pathogens and inflammatory cytokines 42.
T186 5100-5161 Sentence denotes RELA may play an important role in the infection of COVID-19.
T187 5162-5369 Sentence denotes MAPK1 and MAPK14 are members of the MAPK family, which can regulate multiple cellular processes, such as response to oxidative stress, anti-inflammatory, immune response, apoptosis and cell proliferation 43.
T188 5370-5606 Sentence denotes Joseph et al showed SASR-CoV-2 could induce severe inflammation by directly activating p38 MAPK pathway and many p38 MAPK inhibitors are in the clinical stage and should be considered for clinical trial for severe COVID-19 infection 44.
T189 5607-5812 Sentence denotes CASP3 and CASP8, a family of cysteine-dependent proteases, play an important role in these events through activation of other apoptotic proteins mediated by proteolysis and cleavage of nuclear proteins 45.
T190 5813-5945 Sentence denotes In Krahling's study, infection of 293/ACE2 cells with SARS-CoV activated apoptosis-associated events, such as caspase3, caspase 846.
T191 5946-6080 Sentence denotes Therefore, we conclude that CASP3 and CASP8 may be activated and play an important role in the pathophysiological process of COVID-19.
T192 6081-6151 Sentence denotes Higher plasma level of IL-6 was found in ICU patients with COVID-1947.
T193 6152-6362 Sentence denotes Tocilizumab, a recombinant humanized anti-human IL-6 receptor monoclonal antibody, improved the clinical outcome in 20 severe and critical COVID-19 patients and is an effective treatment to reduce mortality 48.
T194 6363-6449 Sentence denotes It has been clinically confirmed that SFJDC is effective in the treatment of COVID-19.
T195 6450-6636 Sentence denotes Wang et al shown that conventional treatment combined with SFJDC treatment for 4 cases of COVID-19 patients could significantly improve symptoms and promote viral negative conversion 49.
T196 6637-6875 Sentence denotes Another study including 70 COVID-19 patients found that SFJDC combined with Arbidol for COVID-19 compared with single using Arbidol could significantly shorten the time of clinical symptoms improvement and COVID-19 negative conversion 50.
T197 6876-6985 Sentence denotes To summarise, the compound and targets of SFJDC were systematically studied by applying network pharmacology.
T198 6986-7070 Sentence denotes Wogonin, licochalcone a and acacetin regulated the most targets associated with NCP.
T199 7071-7195 Sentence denotes RELA, MAPK1, MAPK14, CASP3, CASP8 and IL6 were the core and key genes in the gene-network of SFJDC for the treatment of NCP.
T200 7196-7338 Sentence denotes SFJDC regulated novel coronavirus pneumonia by multi-compound and multi-target, which provided theoretical support for SFJDC against COVID-19.
T201 7339-7400 Sentence denotes More mechanism and roles require further clinical validation.