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LitCovid-sentences  

PMC:7530350 JSONTXT 16 Projects

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Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes Interleukin-6 and severe COVID-19: a systematic review and meta-analysis
T2 74-82 Sentence denotes Abstract
T3 83-93 Sentence denotes Background
T4 94-149 Sentence denotes Evidence links COVID-19 severity to hyper-inflammation.
T5 150-327 Sentence denotes Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19.
T6 328-537 Sentence denotes We, therefore, performed the present systematic review and meta-analysis to investigate whether the circulating levels of IL-6 is a reliable indicator of disease severity among patients affected with COVID-19.
T7 539-546 Sentence denotes Methods
T8 547-653 Sentence denotes A systematic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar on April 19, 2020.
T9 655-662 Sentence denotes Results
T10 663-818 Sentence denotes Eleven studies provided data of IL-6 levels in patients with severe to critical COVID-19 (severe) and patients with mild to moderate COVID-19 (non-severe).
T11 819-873 Sentence denotes The included studies were of moderate to high quality.
T12 874-1035 Sentence denotes The mean patients’ age was 60.9 years, ranging from 45.2 to 76.7 years in the severe group and 46.8 years, ranging from 37.9 to 61 years, in the nonsevere group.
T13 1036-1128 Sentence denotes Fifty-two percent were male in the severe group, as compared to 46% in the non-severe group.
T14 1129-1313 Sentence denotes An overall random effects meta-analysis showed significantly higher serum levels of IL-6 in the severe group than in the non-severe group with a mean difference of +23.1 pg/mL (95% CI:
T15 1314-1376 Sentence denotes 12.42–33.79) and the overall effect of 4.24 (P-value < 0.001).
T16 1377-1498 Sentence denotes Meta-regressions showed that neither age nor sex significantly influenced the mean difference of IL-6 between the groups.
T17 1500-1511 Sentence denotes Conclusions
T18 1512-1640 Sentence denotes Meta-analysis and meta-regression reveal a reliable relationship between IL-6 and COVID-19 severity, independent of age and sex.
T19 1641-1767 Sentence denotes Future research is, however, required to assess the effect of BMI on the pattern of IL-6 production in patients with COVID-19.
T20 1768-1902 Sentence denotes Also, there might be confounding factors that influence the relationship between IL-6 and COVID-19 severity and remain as yet unknown.
T21 1906-1937 Sentence denotes Acknowledgments and disclosures
T22 1938-1997 Sentence denotes Ethics approval and consent to participate: not applicable.
T23 1998-2038 Sentence denotes Consent for publication: not applicable.
T24 2039-2090 Sentence denotes Availability of data and materials: not applicable.
T25 2091-2173 Sentence denotes Conflicts of interests: the authors declare that they have no competing interests.
T26 2174-2225 Sentence denotes Funding: there is no funding for the present study.
T27 2226-2419 Sentence denotes Authors’ contributions: H.M. conceptualized the study, conducted database search, search results screening, detailed review, data extraction, quality assessment, and prepared the initial draft.
T28 2420-2450 Sentence denotes A.S. prepared the final draft.
T29 2451-2519 Sentence denotes N.R. supervised the project and critically appraised the manuscript.
T30 2520-2552 Sentence denotes Acknowledgments: not applicable.