PMC:7519301 / 31142-32111 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T190 0-234 Sentence denotes These findings, together with our results, illustrate that mutations can spread through the population without necessarily having a selective advantage, especially at the beginning of an epidemic when most individuals are susceptible.
T191 235-362 Sentence denotes Mutations occur more frequently after a host switch, and even slightly deleterious mutations may have an opportunity to spread.
T192 363-489 Sentence denotes Hence, the main signal in our study was one of purifying selection that can ultimately eliminate mildly deleterious mutations.
T193 490-969 Sentence denotes Our analyses showed limited evidence of diversifying selection, with comparable substitution rates in structural proteins versus nonstructural proteins (under a selection paradigm, structural proteins which are essential for viral entry and the target of the host immune response would have higher rates than the nonessential proteins), low estimates of genetic differentiation following the initial outbreak, and phylogenetic patterns adhering to a neutral process of evolution.