| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T179 |
0-186 |
Sentence |
denotes |
In the context of rare SARS-CoV-2 mutations, the rapid spread of the D614G mutation is singular and has led authors to hypothesize that viruses with D614G may have enhanced fitness (24). |
| T180 |
187-367 |
Sentence |
denotes |
The strongest evidence of a biological effect for this mutation comes from recent reports of an increase in in vitro infectivity or cell entry for pseudoviruses with D614G (25–28). |
| T181 |
368-596 |
Sentence |
denotes |
Additional work is needed to evaluate whether the increase in infectivity in vitro translates to increased transmissibility (spread) of SARS-CoV-2 across humans, as there is not necessarily a linear relationship between the two. |
| T182 |
597-716 |
Sentence |
denotes |
For example, SARS-CoV mediates cell entry more efficiently than SARS-CoV-2 (with or without the D614G S mutation) (26). |
| T183 |
717-900 |
Sentence |
denotes |
Hence, it would be important to understand whether, controlling for epidemiological factors, there are higher reproduction numbers associated with viruses carrying the D614G mutation. |
| T184 |
901-1247 |
Sentence |
denotes |
While a preliminary comparison of the lineages with either D or G in Washington State did not indicate an obvious advantage for D614G mutants, as they found similar maximal values for the effective reproduction number (https://github.com/blab/ncov-wa-phylodynamics), additional comparisons in different geographic locations should be informative. |
