LitCovid-sentences  

PMC:7519301 / 27004-29125 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T166 0-140 Sentence denotes There remains an urgent need for a SARS-CoV-2 vaccine as a primary countermeasure to mitigate and eventually contain the spread of COVID-19.
T167 141-292 Sentence denotes The virus’s S glycoprotein makes an attractive vaccine target because it plays a key role in mediating virus entry and is known to be immunogenic (40).
T168 293-477 Sentence denotes Neutralizing antibody responses against S have been identified in SARS-CoV-2−infected individuals (2), and several clinical trials for a SARS-CoV-2 vaccine will test S as an immunogen.
T169 478-572 Sentence denotes While we focused on S, our comparative analyses of other proteins yielded similar conclusions:
T170 573-828 Sentence denotes A randomly selected SARS-CoV-2 sequence could be used as a vaccine candidate, given the similarity of any sequence to the computationally derived optimum vaccine candidate (as defined by the MRCAs or consensus sequence based on all circulating sequences).
T171 829-945 Sentence denotes Vaccines developed using any of these sequences should, theoretically, be effective against all circulating viruses.
T172 946-1084 Sentence denotes Vaccine developers could consider designing a vaccine insert with the D614G mutation in S, as this mutation has become dominant worldwide.
T173 1085-1219 Sentence denotes While mutations that become fixed are often linked to the host immune pressure, this seems unlikely for the SARS-CoV-2 mutation D614G.
T174 1220-1384 Sentence denotes Because this residue lies at the interface between two subunits, it would not be expected to be part of a critical epitope for vaccine-mediated protection (Fig. 4).
T175 1385-1501 Sentence denotes As such, pseudoviruses with D614G were as susceptible to neutralization as those with the initial residue D614 (25).
T176 1502-1786 Sentence denotes A mutation, S612L, that emerged in MERS-CoV after passaging the virus in the presence of two antibodies (in 5/15 clones after 20 passages) (41) warrants the evaluation of the analogous D614G mutation in SARS-CoV-2 for its ability to interfere with the recognition of a distal epitope.
T177 1787-1915 Sentence denotes A more direct path to viral escape from antibody recognition would be mutations in the RBD, as described for influenza (42, 43).
T178 1916-2121 Sentence denotes Importantly, we found no mutation in the RBD that was present in more than 1% of SARS-CoV-2 sequences (highest frequency was 0.2% N439K); such rare variants are unlikely to interfere with vaccine efficacy.