PMC:7519301 / 14193-15333 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T95 0-45 Sentence denotes The S mutation D614G quickly became dominant.
T96 46-448 Sentence denotes The mutation D614G was found in 69% of sequences sampled globally as of May 18, 2020, the second most frequent mutation in S was only found in ∼2% of sequences. (A) Number of sequences with D (gray) or G (purple) by continent and sampling date shown cumulatively through the outbreak. (B) Phylogenetic tree reconstructed from all of the ORFs showing the linkage between D614G in S and P4715L in ORF1ab.
T97 449-479 Sentence denotes Tips are colored by continent.
T98 480-703 Sentence denotes The phylogeny suggests that these mutations were linked to a bottleneck event when SARS-CoV-2 viruses were introduced in Europe; this mutation was first seen in Europe in a sequence sampled in Germany at the end of January.
T99 704-1099 Sentence denotes There is no evidence that the increasing predominance of this mutation was caused by convergent selection events that would have occurred in multiple individuals. (C) Overall number of sequences with D614 or D614G across continents; the predominance of D614G in Europe is suggestive of a founder event. (D) Distribution of Hamming distances between sequences with D614, G614 or discordant pairs.
T100 1100-1140 Sentence denotes The median is marked with a dashed line.