| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T4 |
0-227 |
Sentence |
denotes |
WHO convened an Advisory Group (AG) to consider the feasibility, potential value and limitations of establishing a closely-monitored challenge model of experimental SARS-CoV-2 infection and COVID-19 in healthy adult volunteers. |
| T5 |
228-307 |
Sentence |
denotes |
The AG included experts in design, establishment and performance of challenges. |
| T6 |
308-802 |
Sentence |
denotes |
This report summarizes issues that render a COVID-19 model daunting to establish (SARS-CoV-2’s potential to cause severe/fatal illness, its high transmissibility, and lack of a “rescue treatment” to prevent progression from mild/moderate to severe clinical illness) and it proffers prudent strategies for stepwise model development, challenge virus selection, guidelines for manufacturing challenge doses, and ways to contain SARS-CoV-2 and prevent transmission to household/community contacts. |
| T7 |
803-940 |
Sentence |
denotes |
A COVID-19 model could demonstrate protection against virus shedding and/or illness induced by prior SARS-CoV-2 challenge or vaccination. |
| T8 |
941-1120 |
Sentence |
denotes |
A limitation of the model is that vaccine efficacy in experimentally challenged healthy young adults cannot per se be extrapolated to predict efficacy in elderly/high-risk adults. |
