| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T158 |
31-115 |
Sentence |
denotes |
Isolated MSCs are condi-tioned in specialized media that induce release of exosomes. |
| T159 |
116-255 |
Sentence |
denotes |
The MSCs identify the external signal and start to pack regulatory factors in secretory vesicles that are released into the culture medium. |
| T160 |
256-380 |
Sentence |
denotes |
The exosomes are identified and isolated using specific markers, and are then administered intravenously the i.v. injection. |
| T161 |
381-439 |
Sentence |
denotes |
The exosomes inhibit IL-1, IL-6, NK cells, CD4+, and CD8+. |
| T162 |
440-490 |
Sentence |
denotes |
This results in suppression of the cytokine storm. |
| T163 |
491-614 |
Sentence |
denotes |
Exosomes also activate IL-10, TGF-βeta, M2 macrophages, and T and B regulatory cells to further suppress the immune system. |
| T164 |
615-715 |
Sentence |
denotes |
This reduces the proinflammatory cytokines, alleviating symptoms and aiding in recovery of patients. |
