LitCovid-sentences  

PMC:7473478 / 13474-16197 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T108 0-115 Sentence denotes Stem cells have been studied extensively for their ability to regenerate and for the treatment of various diseases.
T109 116-261 Sentence denotes Recently, we devised an improved protocol for the isolation of urine-derived stem cells and their further differentiation into immune cells (95).
T110 262-378 Sentence denotes Moreover, our research group promoted the hematopoietic differentiation of hiPSCs using a novel small molecule (96).
T111 379-513 Sentence denotes At the advent of COVID-19, it has become mandatory to discover therapeutic strategies that are easily reproducible and cost effective.
T112 514-613 Sentence denotes Drugs currently available for the treatment of COVID-19 include ones that target viral replication.
T113 614-787 Sentence denotes These drugs include camo-stat mesylate, which is involved in the inhibition of viral fusion to the cell membrane, and favipiravir and remdesivir, which are anti-viral drugs.
T114 788-968 Sentence denotes However, because the cytokine storm is found predominantly in COVID-19 patients, it is essential to consider drugs that inhibit viral replication while treating the cytokine storm.
T115 969-1041 Sentence denotes Hence, MSC-Exos may be appropriate therapeutic agents for COVID-19 (97).
T116 1042-1183 Sentence denotes MSCs can be more advantageous than other anti-inflammatory agents, because they can provide immunomodulatory effects based on the host cells.
T117 1184-1420 Sentence denotes In addition to these effects, MSCs can prevent fibrosis of tissues, enable reversal of lung dysfunction, and aid in the regeneration of damaged tissue, which can be significantly beneficial for COVID-19-associated organ damage (98, 99).
T118 1421-1583 Sentence denotes Because the healing properties of the MSCs can be primarily attributed to the secretomes or exosomes, using them may be more effective than using MSCs themselves.
T119 1584-1720 Sentence denotes Exosomes can be mass-produced, administered systematically with minimaltoxicity, and be able to reach the cell targets more efficiently.
T120 1721-1841 Sentence denotes In addition to their inherent immunomodulatory potential, the MSC-Exos can also be used as a drug-delivery system (100).
T121 1842-2035 Sentence denotes MSC-Exos can be modified in vivo to release exosomes that have a higher immunomodulatory potential (101) and can be cultured using various cytokines to exhibit an anti-inflammatory state (102).
T122 2036-2182 Sentence denotes Although MSC-Exos appear to be promising thera-peutic agents for COVID-19, more experimental research is necessary for them to be used clinically.
T123 2183-2304 Sentence denotes Moreover, it is es-sential to optimize the protocols for storage and isolation of MSC-Exos for the treatment of COVID-19.
T124 2305-2453 Sentence denotes It is also imperative to do experiments to understand the underlying mechanisms of COVID-19 in order to optimize MSC-Exo therapy for treatment (97).
T125 2454-2573 Sentence denotes Further, it is also essential to find the optimum dosage, route of administration, and treatment schedule for MSC-Exos.
T126 2574-2723 Sentence denotes Hence, since MSCs are more widely studied in these aspects than are MSC-Exos, they are predominantly preferred in clinical trials for COVID-19 (103).