LitCovid-sentences  

PMC:7464116 / 86813-90372 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T523 0-63 Sentence denotes Table 1 Summary of the main evidence emerging from the review.
T524 64-79 Sentence denotes - Key-Messages
T525 80-356 Sentence denotes Epidemiology The most common chronic preexisting diseases in deceased COVID-19 patients were diabetes mellitus, COPD, arterial hypertension, atrial fibrillation, chronic kidney disease (CKD), active cancer within the previous 5 years, ischemic heart disease and obesity [19].
T526 357-436 Sentence denotes CKD was present in more than 20% of the deceased patients due to COVID-19 [20].
T527 437-647 Sentence denotes Pathophysiology SARS-CoV-2 invades the target cells through a multi-step process that involves cell internalization through interaction with the ACE-2 receptor and priming by the cell protease TMPRSS2 [35,62].
T528 648-809 Sentence denotes The spike glycoprotein receptor binding domain (RBD) has biomolecular characteristics that are probably responsible for the greater diffusion of SARS-CoV-2 [42].
T529 810-944 Sentence denotes The renal damage observed in COVID-19 patients is the result of complex mechanisms induced directly and indirectly by SARS-CoV-2 [35].
T530 945-1110 Sentence denotes The two main pathophysiological mechanisms of kidney damage are direct cytopathic effect of SARS-CoV-2 on renal epithelial cells and cytokine storm syndrome [64,71].
T531 1111-1318 Sentence denotes Hypoxia, persistent hypotension, rhabdomyolysis, over activation of the coagulation cascade and impairment of microcirculation play a role in the predisposition to the development of acute renal damage [64].
T532 1319-1453 Sentence denotes Histopathology SARS-CoV-2 infection induces acute tubular necrosis through direct cytotoxicity and in immune mediated damage [62,63].
T533 1454-1507 Sentence denotes Light microscopy: acute renal proximal tubule injury.
T534 1508-1610 Sentence denotes Immunohistochemistry: viral nucleocapsid protein into the renal tubular cells of the infected tissues.
T535 1611-1766 Sentence denotes Transmission electron microscopy: viral inclusion bodies in a peritubular space and viral particles in endothelial cells of the glomerular capillary loops.
T536 1767-1946 Sentence denotes Clinical Features COVID-19 patients with elevated baseline serum creatinine are more likely to be admitted to the intensive care unit and to undergo mechanical ventilation [106].
T537 1947-2020 Sentence denotes Kidney disease on admission is a higher risk of negative prognosis [106].
T538 2021-2113 Sentence denotes COVID-19 patients with AKI had ~5.3 times mortality risk higher than those without AKI [25].
T539 2114-2191 Sentence denotes The incidence of AKI in the overall cohort was in a range of 4.7–7.5% [8,15].
T540 2192-2428 Sentence denotes Dialysis patients have a higher rate of contracting SARS compared with the one of the general population, but both the degree of disease severity and the mortality rate of the dialysis group were similar to the general population [113].
T541 2429-2566 Sentence denotes SARS-CoV-2 was detected in peritoneal fluid; peritoneal dialysis patients have a higher mortality rate than the general population [119].
T542 2567-2810 Sentence denotes Kidney transplant patients have a higher mortality rate than the general population; the clinical manifestations were similar to those reported for the general population, more than half of the patients were successfully discharged home [119].
T543 2811-3146 Sentence denotes Management The diffusion of hygienic-behavioral rules among nephropathic patients and the preventive measures implemented in the various nephrological centers have proven effective in containing the diffusion of COVID-19 among patients with chronic kidney disease (on dialysis and non-dialysis) and transplanted kidney patients [137].
T544 3147-3201 Sentence denotes There is no vaccine and therapy specific for COVID-19.
T545 3202-3270 Sentence denotes Most of vaccine candidates are still in the preclinical phase [149].
T546 3271-3494 Sentence denotes Chronic renal failure patients receive the same therapeutic protocols as the general population; these include antiviral drugs, tocilizumab, low molecular weight heparin, hydroxychloroquine (recently stopped by AIFA) [150].
T547 3495-3559 Sentence denotes Interferons have also been proposed as a possible therapy [158].