LitCovid-sentences  

PMC:7464116 / 82225-86130 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T492 0-19 Sentence denotes Overview of Therapy
T493 20-132 Sentence denotes COVID-19 treatment is essentially supportive and, in fact, specific vaccines or therapies are not yet available.
T494 133-209 Sentence denotes The COVID-19 vaccine is considered to be an effective prophylactic strategy.
T495 210-310 Sentence denotes About 90 institutions around the world are working on identifying a specific and safe vaccine [148].
T496 311-435 Sentence denotes As of 8 April 2020, the global research and development landscape for COVID-19 vaccines has included 115 vaccine candidates.
T497 436-733 Sentence denotes Most of these are currently in the preclinical phase and only some of these (mRNA-1273 from Moderna, Ad5-nCoV from CanSino Biologicals, INO-4800 from Inovio and LV-SMENP-DC and pathogen-specific aAPC from Shenzhen Geno-Immune Medical Institute) have recently moved into clinical development [149].
T498 734-900 Sentence denotes The therapeutic protocols used for the general population have also been adopted in patients with chronic renal failure, regardless of the stage of the disease [150].
T499 901-1215 Sentence denotes Antiviral drugs (Lopinavir/ritonavir (200/50 mg 2 cp × 2/day), Darunavir (800 mg/day), Ritonavir (100 mg/day), Darunavir/cobicistat (800/150 mg/day)) have been effective for the management of SARS-CoV-2 infection, in asymptomatic/paucisymptomatic patients and in patients with more severe manifestations [150,151].
T500 1216-1445 Sentence denotes Hydroxychloroquine (known as an antimalarial drug) was successfully used in the early stages of the pandemic until May 26th, 2020, when AIFA suspended authorization for its use for the treatment of SARS-CoV-2 infection [152,153].
T501 1446-1678 Sentence denotes Tocilizumab (anti-IL-6 monoclonal antibody) has been used in association with steroids and/or antiviral drugs, for the treatment of more severe clinical cases and patients with rapidly and significantly increasing levels of D-dimer.
T502 1679-1801 Sentence denotes The dosage is 8 mg/kg body weight with a maximum infusion dose of 800 mg for a maximum of three administrations [154,155].
T503 1802-1959 Sentence denotes Unlike hydroxychloroquine, both antiviral drugs and tocilizumab do not require dosage adjustments in relation to the values of the glomerular filtrate [150].
T504 1960-2169 Sentence denotes Given the state of hypercoagulability and the high incidence of thromboembolic complications in COVID-19 patients, high doses of low molecular weight heparin have been added to the therapeutic protocols [156].
T505 2170-2380 Sentence denotes For kidney transplant patients, immunosuppressive therapy must be reshaped, in particular, mycophenolate, azathioprine and calcineurin inhibitors must be suspended during the active phases of the disease [150].
T506 2381-2488 Sentence denotes Tocilizumab, on the other hand, may be effective in these patients, but randomized trials are needed [157].
T507 2489-3015 Sentence denotes For COVID-19 patients undergoing intermittent dialysis, the methods that obtain the greatest clearance of the pro-inflammatory molecules are preferred; in patients with AKI, hemodynamically unstable and requiring dialysis, continuous dialysis treatments are preferred (CVVH with pre and post-dilution at a dose > 25 mL/Kg/h), using citrate as the first choice anticoagulant (after serial assessments of serum calcium and lactic acid) and, alternatively, unfractionated heparin (constantly monitoring the patient’s APPT) [150].
T508 3016-3250 Sentence denotes Interferons have also been proposed as a possible therapy, although the timing of their use is critical since their benefit is realized if given before or early on in infection and may actually be harmful if given in the later stages.
T509 3251-3310 Sentence denotes Clinical studies are underway to test their efficacy [158].
T510 3311-3517 Sentence denotes A recent phosphoproteomics analysis of SARS-CoV-2 infected Vero E6 cells (a cell line derived from monkey kidney epithelial cells) showed dramatic changes in phosphorylation of both host and viral proteins.
T511 3518-3651 Sentence denotes Furthermore, viral infection induced the formation of casein kinase II (CK2)-containing filopodia containing budding viral particles.
T512 3652-3836 Sentence denotes The authors have stated that pharmacologic inhibition of several kinases including CK2 and p38 MAP (mitogen-activated protein) kinases may be potential future COVID-19 therapies [159].
T513 3837-3905 Sentence denotes A summary of the main contents of this paper is depicted in Table 1.