LitCovid-sentences  

PMC:7463108 / 93932-95637 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1201 0-105 Sentence denotes Postmortem clinical studies indicate the endogenous opioid system is disrupted in neuroHIV (Gelman et al.
T1202 106-126 Sentence denotes 2012; Yuferov et al.
T1203 127-133 Sentence denotes 2014).
T1204 134-210 Sentence denotes Specifically, OPRK1 mRNA is significantly upregulated in PWH (Yuferov et al.
T1205 211-271 Sentence denotes 2014) and in transgenic neuroHIV rodent models (Chang et al.
T1206 272-292 Sentence denotes 2007; Fitting et al.
T1207 293-441 Sentence denotes 2010b) potentially as a compensatory neuroprotective function in response to inflammatory processes in the presence of HIV infection (Yuferov et al.
T1208 442-448 Sentence denotes 2014).
T1209 449-632 Sentence denotes The upregulation of mRNA coding OPRK1 is triggered by factors released by activated macrophages and glia and is supported by mechanistic studies in dorsal root ganglia (Puehler et al.
T1210 633-656 Sentence denotes 2006; Gabrilovac et al.
T1211 657-663 Sentence denotes 2012).
T1212 664-882 Sentence denotes Since leukocytes, including macrophages, can express β-endorphin and enkephalins, it is important to consider the potential influence of leukocyte-derived endogenous opioid peptides in neuroinflammation (Rittner et al.
T1213 883-889 Sentence denotes 2001).
T1214 890-1060 Sentence denotes Granulocytes express about 10-fold higher levels of β-endorphin, a preferential MOR and lower affinity KOR endogenous ligand, than lymphocytes (Pallinger and Csaba 2008).
T1215 1061-1157 Sentence denotes Increases in β-endorphin expression by peripheral blood mononuclear cells (PBMCs) (Gironi et al.
T1216 1158-1177 Sentence denotes 2000; Gironi et al.
T1217 1178-1246 Sentence denotes 2003), coincide with inflammation and relapse in multiple sclerosis.
T1218 1247-1597 Sentence denotes Moreover, increases in inflammatory cytokines, such as interleukin-1β (IL-1β), have been demonstrated to differentially increase the expression of proenkephalin transcripts in primary astrocytes cultured from different brain regions (Ruzicka and Akil 1997) and increase IL-10-stimulated β-endorphin expression in cultured primary microglia (Wu et al.
T1219 1598-1604 Sentence denotes 2017).
T1220 1605-1698 Sentence denotes Interestingly, OPRM1 mRNA levels do not differ between HIV+ and HIV− subjects (Yuferov et al.
T1221 1699-1705 Sentence denotes 2014).