| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1120 |
0-151 |
Sentence |
denotes |
The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. |
| T1121 |
152-189 |
Sentence |
denotes |
2009), and astrocytes (Mahajan et al. |
| T1122 |
190-196 |
Sentence |
denotes |
2002). |
| T1123 |
197-420 |
Sentence |
denotes |
Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. |
| T1124 |
421-427 |
Sentence |
denotes |
2002). |
| T1125 |
428-570 |
Sentence |
denotes |
Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. |
| T1126 |
571-587 |
Sentence |
denotes |
2008a) (Fig. 1). |
| T1127 |
588-883 |
Sentence |
denotes |
Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. |
| T1128 |
884-900 |
Sentence |
denotes |
2008a) (Fig. 1). |
