LitCovid-sentences  

PMC:7463108 / 77998-79627 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T1063 0-217 Sentence denotes Gene polymorphisms of opioid (OPRM1 and OPRK1) and non-opioid (e.g., DRD1 and DRD2) drug/neurotransmitter receptor genes are associated with altered HIV infectivity, viral loads and CD4+ cell counts (Proudnikov et al.
T1064 218-236 Sentence denotes 2012; Regan et al.
T1065 237-256 Sentence denotes 2012; Jacobs et al.
T1066 257-280 Sentence denotes 2013; Proudnikov et al.
T1067 281-299 Sentence denotes 2013; Dever et al.
T1068 300-306 Sentence denotes 2014).
T1069 307-388 Sentence denotes Not only do MORs mediate the behavioral consequences of opiate abuse (Bond et al.
T1070 389-407 Sentence denotes 1998; Szeto et al.
T1071 408-426 Sentence denotes 2001; Ikeda et al.
T1072 427-445 Sentence denotes 2005; Kreek et al.
T1073 446-461 Sentence denotes 2005; Xu et al.
T1074 462-673 Sentence denotes 2014b), but the ability of MOR to modulate HIV chemokine co-receptor signaling through cross desensitization or through direct molecular interactions suggest MOR may influence HIV infectivity at multiple levels.
T1075 674-915 Sentence denotes The unique ability of MOR to modulate HIV co-receptor function, prompted inquiry regarding whether variants of the OPRM1 gene (polymorphisms or splicing variants) might differentially effect HIV infectivity and/or opiate addictive behaviors.
T1076 916-1103 Sentence denotes In a sample of 1031 HIV-1-infected women, 18 OPRM1 polymorphisms were significantly associated with decreases or increases in HIV infectivity and responsiveness to cART (Proudnikov et al.
T1077 1104-1110 Sentence denotes 2012).
T1078 1111-1218 Sentence denotes Other gene polymorphisms, such as enzymes affecting drug metabolism (Meyer and Zanger 1997; Benowitz et al.
T1079 1219-1336 Sentence denotes 2006) and other neurochemical systems (Herman and Balogh 2012; Koob and Volkow 2016) can also affect drug dependence.
T1080 1337-1498 Sentence denotes The A118G variant of OPRM1 alters the regulation of proinflammatory cytokine secretion (i.e., TNF-α, IL-10, IFN-γ) from peripheral immune cells (Matsunaga et al.
T1081 1499-1505 Sentence denotes 2009).
T1082 1506-1629 Sentence denotes Overall, these findings suggest that polymorphisms in MOR ligands/genes (OPRM1) can influence the pathophysiology of HIV-1.