| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T65 |
0-174 |
Sentence |
denotes |
Up to 90% of post-mortem tissues sampled from opiate abusers display brain edema (Buttner 2011), astrogliosis and microgliosis especially in the hippocampus (Oehmichen et al. |
| T66 |
175-248 |
Sentence |
denotes |
1996), white matter, and subcortical regions at autopsy (Tomlinson et al. |
| T67 |
249-269 |
Sentence |
denotes |
1999; Anthony et al. |
| T68 |
270-290 |
Sentence |
denotes |
2005; Buttner et al. |
| T69 |
291-320 |
Sentence |
denotes |
2006; Buttner and Weis 2006). |
| T70 |
321-509 |
Sentence |
denotes |
The reactive gliosis is accompanied by increases in proinflammatory cytokines and inflammatory mediators, including TNF-α, IL-1β, and nitric oxide synthase (NOS) (Dyuizen and Lamash 2009). |
| T71 |
510-780 |
Sentence |
denotes |
Opiates especially drive the enhanced activation of heme-oxygenase, NOS, and cyclic GMP-dependent-protein kinase (Liang and Clark 2004) and production of reactive nitrogen species (RNS) such as peroxynitrite (Salvemini 2009), and resultant nitrosative damage (Zou et al. |
| T72 |
781-787 |
Sentence |
denotes |
2011). |
| T73 |
788-869 |
Sentence |
denotes |
Nitrosative damage is an important endpoint for opiate exposure (Pasternak et al. |
| T74 |
870-1038 |
Sentence |
denotes |
1995; Liang and Clark 2004; Salvemini 2009) and key site of convergence for the oxidative stress accompanying HIV protein exposure (Hauser and Knapp 2014; McLane et al. |
| T75 |
1039-1045 |
Sentence |
denotes |
2018). |
