LitCovid-sentences  

PMC:7463108 / 68676-70486 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T950 0-107 Sentence denotes Besides being able to infect hNPCs, HIV may also affect their maturation and the fate of neural stem cells.
T951 108-172 Sentence denotes That HIV or gp120 can inhibit adult neurogenesis (Okamoto et al.
T952 173-189 Sentence denotes 2007; Lee et al.
T953 190-212 Sentence denotes 2013; Putatunda et al.
T954 213-297 Sentence denotes 2018) has been the topic of past reviews (Schwartz and Major 2006; Venkatesan et al.
T955 298-315 Sentence denotes 2007; Peng et al.
T956 316-392 Sentence denotes 2008, 2011; Ferrell and Giunta 2014; Hauser and Knapp 2014; Putatunda et al.
T957 393-399 Sentence denotes 2019).
T958 400-607 Sentence denotes How HIV inhibits the self-renewal, tripotential differentiation, and survival of neural progenitors/stem cells or the genesis of adult neurons in the subgranular zone (SGZ) of the dentate gyrus is uncertain.
T959 608-785 Sentence denotes HIV and gp120 [via actions at the same chemokine receptor(s) (Tran and Miller 2005; Li and Ransohoff 2008)] are proposed to modulate the adult neurogenesis via Notch (Fan et al.
T960 786-911 Sentence denotes 2016), by obstructing a cell cycle checkpoint via the activation MAPK-activated protein kinase 2 and Cdc25B/C (Okamoto et al.
T961 912-989 Sentence denotes 2007), or through signaling by platelet-derived growth factor BB (Chao et al.
T962 990-1015 Sentence denotes 2014) or BDNF (Lee et al.
T963 1016-1022 Sentence denotes 2013).
T964 1023-1312 Sentence denotes The extent that HIV regulates the genesis of neural progenitors within the subventricular zone of the developing CNS through similar mechanisms as in the adult SGZ of the dentate gyrus is uncertain—even though HIV disrupts the generation of neurons and glia during maturation or in adults.
T965 1313-1482 Sentence denotes For example, MAPK/ERK1/2 enhances p53- and p21-dependent downregulation of cyclin D1 hindering progression through the G1 phase of the cell cycle in hNPCs (Mishra et al.
T966 1483-1501 Sentence denotes 2010; Malik et al.
T967 1502-1508 Sentence denotes 2014).
T968 1509-1681 Sentence denotes Importantly, opioids too can affect the genesis of neurons and glia during maturation or in the adult directly via convergent pathways (Hauser and Knapp 2018; Kibaly et al.
T969 1682-1810 Sentence denotes 2018) suggesting yet another site of opioid and HIV interactions in dysregulating the creation and fate of new neurons and glia.