LitCovid-sentences  

PMC:7463108 / 66268-67441 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T912 0-119 Sentence denotes Despite long-standing evidence of white matter damage early during the infection even in asymptomatic PWH (Price et al.
T913 120-137 Sentence denotes 1988; Gray et al.
T914 138-155 Sentence denotes 1996; Chen et al.
T915 156-181 Sentence denotes 2009; Stubbe-Drger et al.
T916 182-201 Sentence denotes 2012; Jensen et al.
T917 202-307 Sentence denotes 2019), few studies have examined how opiate exposure affects OLs and myelin in neuroHIV (Tables 1 and 2).
T918 308-453 Sentence denotes Increased demyelination is reported in SIV-infected rhesus macaques chronically treated with morphine (4× daily, up to 59 weeks) (Marcario et al.
T919 454-460 Sentence denotes 2008).
T920 461-633 Sentence denotes Specifically, morphine-treated SIV macaques developed more subtle, focal, dysmyelinating lesions, with accumulations of macrophages in areas of myelin loss (Marcario et al.
T921 634-689 Sentence denotes 2008), as well as accompanying gliosis (Marcario et al.
T922 690-715 Sentence denotes 2008; Rivera-Amill et al.
T923 716-737 Sentence denotes 2010a; Bokhari et al.
T924 738-744 Sentence denotes 2011).
T925 745-964 Sentence denotes Morphine exposure increased degeneration of OLs in Tat+ mice, which was accompanied by elevations in caspase-3 activation and TUNEL reactivity in OLs and reversible by naloxone or naltrexone, respectively (Hauser et al.
T926 965-971 Sentence denotes 2009).
T927 972-1035 Sentence denotes Although OLs can express MOR both in vivo (Stiene-Martin et al.
T928 1036-1069 Sentence denotes 2001) and in vitro (Hauser et al.
T929 1070-1173 Sentence denotes 2009), it remains unclear the extent to which MOR activation in OLs directly mediates HIV pathogenesis.