Id |
Subject |
Object |
Predicate |
Lexical cue |
T891 |
0-164 |
Sentence |
denotes |
Opioid abuse by itself can result in demyelination, leukoencephalopathy, and lesions in white matter (Offiah and Hall 2008; Eran and Barak 2009; Morales Odia et al. |
T892 |
165-182 |
Sentence |
denotes |
2010; Bora et al. |
T893 |
183-198 |
Sentence |
denotes |
2012; Li et al. |
T894 |
199-305 |
Sentence |
denotes |
2013), and the degree of myelin disruption correlates with the duration of opiate dependence (Ivers et al. |
T895 |
306-312 |
Sentence |
denotes |
2018). |
T896 |
313-530 |
Sentence |
denotes |
Chronic oxycodone exposure in rats causes some axonopathies and reduces the size of axonal fascicles, decreases myelin basic protein levels, and causes the accumulation of amyloid-β precursor protein (APP) (Fan et al. |
T897 |
531-537 |
Sentence |
denotes |
2018). |
T898 |
538-693 |
Sentence |
denotes |
Most preclinical studies have examined the effects of opioids and opioid receptor blockade on OL maturation and/or the timing of myelination (Hauser et al. |
T899 |
694-712 |
Sentence |
denotes |
1993; Knapp et al. |
T900 |
713-739 |
Sentence |
denotes |
1998; Stiene-Martin et al. |
T901 |
740-760 |
Sentence |
denotes |
2001; Sanchez et al. |
T902 |
761-779 |
Sentence |
denotes |
2008; Knapp et al. |
T903 |
780-807 |
Sentence |
denotes |
2009; Vestal-Laborde et al. |
T904 |
808-814 |
Sentence |
denotes |
2014). |
T905 |
815-893 |
Sentence |
denotes |
OLs can transiently express MORs and other opioid receptor types (Knapp et al. |
T906 |
894-918 |
Sentence |
denotes |
1998; Tryoen-Toth et al. |
T907 |
919-937 |
Sentence |
denotes |
2000; Knapp et al. |
T908 |
938-964 |
Sentence |
denotes |
2001; Stiene-Martin et al. |
T909 |
965-971 |
Sentence |
denotes |
2001). |
T910 |
972-1099 |
Sentence |
denotes |
Selective MOR and possibly KOR activation can directly modulate the growth of OLs in vitro (Knapp and Hauser 1996; Knapp et al. |
T911 |
1100-1112 |
Sentence |
denotes |
1998, 2001). |