PMC:7463108 / 65155-66267 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T891 0-164 Sentence denotes Opioid abuse by itself can result in demyelination, leukoencephalopathy, and lesions in white matter (Offiah and Hall 2008; Eran and Barak 2009; Morales Odia et al.
T892 165-182 Sentence denotes 2010; Bora et al.
T893 183-198 Sentence denotes 2012; Li et al.
T894 199-305 Sentence denotes 2013), and the degree of myelin disruption correlates with the duration of opiate dependence (Ivers et al.
T895 306-312 Sentence denotes 2018).
T896 313-530 Sentence denotes Chronic oxycodone exposure in rats causes some axonopathies and reduces the size of axonal fascicles, decreases myelin basic protein levels, and causes the accumulation of amyloid-β precursor protein (APP) (Fan et al.
T897 531-537 Sentence denotes 2018).
T898 538-693 Sentence denotes Most preclinical studies have examined the effects of opioids and opioid receptor blockade on OL maturation and/or the timing of myelination (Hauser et al.
T899 694-712 Sentence denotes 1993; Knapp et al.
T900 713-739 Sentence denotes 1998; Stiene-Martin et al.
T901 740-760 Sentence denotes 2001; Sanchez et al.
T902 761-779 Sentence denotes 2008; Knapp et al.
T903 780-807 Sentence denotes 2009; Vestal-Laborde et al.
T904 808-814 Sentence denotes 2014).
T905 815-893 Sentence denotes OLs can transiently express MORs and other opioid receptor types (Knapp et al.
T906 894-918 Sentence denotes 1998; Tryoen-Toth et al.
T907 919-937 Sentence denotes 2000; Knapp et al.
T908 938-964 Sentence denotes 2001; Stiene-Martin et al.
T909 965-971 Sentence denotes 2001).
T910 972-1099 Sentence denotes Selective MOR and possibly KOR activation can directly modulate the growth of OLs in vitro (Knapp and Hauser 1996; Knapp et al.
T911 1100-1112 Sentence denotes 1998, 2001).