LitCovid-sentences  

PMC:7463108 / 63836-65154 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T868 0-64 Sentence denotes HIV likely damages OLs through both direct and indirect actions.
T869 65-140 Sentence denotes OLs lack CD4, and reports of OL infection by HIV are variable (Esiri et al.
T870 141-162 Sentence denotes 1991; Albright et al.
T871 163-189 Sentence denotes 1996; Wohlschlaeger et al.
T872 190-298 Sentence denotes 2009); thus, HIV infection of OLs is unlikely a major avenue of OL or white matter damage (discussed below).
T873 299-486 Sentence denotes Alternatively, bystander damage to OLs through the production of “virotoxins” and “cellular toxins” (Nath 1999) by infected neighboring cells is more likely to be operative (Hauser et al.
T874 487-503 Sentence denotes 2009; Zou et al.
T875 504-523 Sentence denotes 2015; Jensen et al.
T876 524-540 Sentence denotes 2019; Zou et al.
T877 541-547 Sentence denotes 2019).
T878 548-602 Sentence denotes ARVs also contribute to OL cytotoxicity (Jensen et al.
T879 603-621 Sentence denotes 2015; Festa et al.
T880 622-641 Sentence denotes 2019; Jensen et al.
T881 642-648 Sentence denotes 2019).
T882 649-840 Sentence denotes HIV-1 Tat directly induces damage in isolated OLs through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/N-methyl-D-aspartic acid (NMDA) receptor-dependent mechanisms (Zou et al.
T883 841-910 Sentence denotes 2015) and is also associated with abnormal Kv1.3 activity (Liu et al.
T884 911-917 Sentence denotes 2017).
T885 918-1014 Sentence denotes Immature OLs are preferentially targeted by Tat compared to differentiated OLs (Khurdayan et al.
T886 1015-1032 Sentence denotes 2004; Hahn et al.
T887 1033-1049 Sentence denotes 2012; Zou et al.
T888 1050-1062 Sentence denotes 2015, 2019).
T889 1063-1311 Sentence denotes While the reasons why immature OLs are more susceptible to Tat are unclear, unlike mature OLs, Tat preferentially upregulates GSK-3β signaling in undifferentiated OLs by inhibiting Ca2+/calmodulin-dependent protein kinase II β (CaMKIIβ) (Zou et al.
T890 1312-1318 Sentence denotes 2019).