LitCovid-sentences  

PMC:7463108 / 59485-60776 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T806 0-162 Sentence denotes HIV, HIV-1 viral proteins, and opiate-induced barrier dysfunction is associated with increased infiltration of monocyte-derived macrophages (MDMs) into the brain.
T807 163-309 Sentence denotes Enhanced influx of peripheral (infected) macrophages into the brain can serve to replenish viral reservoirs and further promote neuroinflammation.
T808 310-448 Sentence denotes Several studies have examined the individual impact of HIV, Tat, or morphine on monocyte adhesion or migration into the CNS (Nottet et al.
T809 449-464 Sentence denotes 1996; Wu et al.
T810 465-491 Sentence denotes 2000; Fischer-Smith et al.
T811 492-510 Sentence denotes 2001; Pello et al.
T812 511-532 Sentence denotes 2006; Williams et al.
T813 533-560 Sentence denotes 2013a, 2014; Strazza et al.
T814 561-582 Sentence denotes 2016; Leibrand et al.
T815 583-604 Sentence denotes 2017; Chilunda et al.
T816 605-611 Sentence denotes 2019).
T817 612-693 Sentence denotes However, fewer studies have examined the combined effects of HIV/Tat and opiates.
T818 694-852 Sentence denotes Co-exposure of HIV-1 Tat and morphine on astrocytes increases the production of chemoattractants, primarily CCL2 and CCL5, and increases microglial migration.
T819 853-913 Sentence denotes These effects were inhibited by MOR blockade (El-Hage et al.
T820 914-921 Sentence denotes 2006b).
T821 922-1076 Sentence denotes Co-exposure of Tat and morphine or buprenorphine to a BBB model increases monocyte transmigration in response to CCL5 and other chemokines (Mahajan et al.
T822 1077-1110 Sentence denotes 2008; Jaureguiberry-Bravo et. al.
T823 1111-1117 Sentence denotes 2016).
T824 1118-1291 Sentence denotes In S. pneumoniae-infected mice, morphine and/or Tat exposure significantly enhances immune cell trafficking into the brain via actions at TLR2 and TLR4 (Dutta and Roy 2015).