LitCovid-sentences  

PMC:7463108 / 47354-48991 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T699 0-111 Sentence denotes Unlike in astrocytes, opiate and HIV interactions in microglia tend to be self-limiting (Turchan-Cholewo et al.
T700 112-118 Sentence denotes 2009).
T701 119-303 Sentence denotes Opiates initially trigger large increases in the production of proinflammatory cytokines (Hauser, unpublished), reactive oxygen (ROS) and nitrogen (RNS) species (Turchan-Cholewo et al.
T702 304-353 Sentence denotes 2009), and the release of glutamate (Gupta et al.
T703 354-435 Sentence denotes 2010) and ATP (Sorrell and Hauser 2014) extracellularly in Tat-exposed microglia.
T704 436-557 Sentence denotes The release of glutamate is mediated by the catalytic subunit of the cystine-glutamate antiporter xc− (xCT) (Gupta et al.
T705 558-564 Sentence denotes 2010).
T706 565-804 Sentence denotes Interestingly, following acute increases in the release of cytokines (e.g., TNF-α; unpublished), morphine no longer increases Tat-induced cytokine levels at 24 h; instead, their levels are reduced by opiate-dependent proteasome inhibition.
T707 805-1034 Sentence denotes The proteasome inhibitor, MG115, mimics the effects of morphine in decreasing proteasome activity at 24 h and blocks TNFα, IL-6, and CCL2 release from microglia, but does not increase ROS or RNS production (Turchan-Cholewo et al.
T708 1035-1041 Sentence denotes 2009).
T709 1042-1208 Sentence denotes The ubiquitin proteasome system (UPS) is typically viewed as contributing to opiate tolerance and physical dependence by modulating MOR downregulation (Massaly et al.
T710 1209-1228 Sentence denotes 2014; Caputi et al.
T711 1229-1282 Sentence denotes 2019), rather than MOR activity constraining the UPS.
T712 1283-1630 Sentence denotes Thus, while HIV-exposed, MOR-expressing microglia show a burst of ROS and proinflammatory cytokine production in response to morphine, the cytokine release collapses within 24 h seemingly because sustained opiate exposure inhibits the UPS thereby preventing degradation of the IκB subunit and nuclear translocation of NF-κB (Turchan-Cholewo et al.
T713 1631-1637 Sentence denotes 2009).