PMC:7463108 / 4483-5718 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T38 0-110 Sentence denotes The current opioid crisis did not happen quickly; in fact, it has been described as occurring in three phases.
T39 111-206 Sentence denotes The first phase began in the late 1990s with an increase in the number of prescription opioids.
T40 207-331 Sentence denotes This led to overdose deaths that were attributable to natural and semi-synthetic opioids, such as methadone (Kolodyny et al.
T41 332-348 Sentence denotes 2015; CDC 2017).
T42 349-452 Sentence denotes The second phase began in 2010 in which heroin took the lead as the principal cause of overdose deaths.
T43 453-622 Sentence denotes The most recent, third wave, began in 2013 in which highly potent synthetic opioids, such as fentanyl and its analogs became the main cause of mortality (Kolodyny et al.
T44 623-639 Sentence denotes 2015; CDC 2017).
T45 640-763 Sentence denotes The entry of fentanyl and its analogs into the clandestine market has changed the dynamics of the opioid market in the U.S.
T46 764-987 Sentence denotes The synthetic opioids, such as fentanyl, are several orders of magnitude more potent than morphine, easily smuggled, and frequently and inconsistently mixed with lower quality drugs increasing the probability of overdosing.
T47 988-1064 Sentence denotes According to the National Forensic Laboratory Information System of the U.S.
T48 1065-1235 Sentence denotes Drug Enforcement Administration (DEA), fentanyl accounted for one-third of the illicit opioids seized in 2017 (UNODC 2019c) and has become a global problem (UNODC 2019b).