LitCovid-sentences  

PMC:7463108 / 30520-41055 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T430 0-54 Sentence denotes Table 2 Cellular and molecular interactions (in vitro)
T431 55-138 Sentence denotes Major effects HIV pathogena ARV Opioids Outcome Model system (in vitro) Citation(s)
T432 139-149 Sentence denotes Mixed-Glia
T433 150-183 Sentence denotes HIV expression HIV No • Dynorphin
T434 184-193 Sentence denotes • U50,488
T435 194-230 Sentence denotes (KOR agonists) • ↑ HIV-1 expression,
T436 231-361 Sentence denotes • Dynorphin (KOR agonist) ↑ TNF-α, IL-6 mRNA and protein Human fetal neural cells, HIV-infected promonocyte (U1) line (Chao et al.
T437 362-367 Sentence denotes 1995)
T438 368-389 Sentence denotes HIVSF162 No • U50,488
T439 390-399 Sentence denotes • U69,593
T440 400-416 Sentence denotes • Dynorphin1–17;
T441 417-431 Sentence denotes (KOR agonists)
T442 432-541 Sentence denotes • Morphine • KOR agonists ± TNF-α differentially ↓ HIV p24 Human, primary mixed neurons and glia (Chao et al.
T443 542-548 Sentence denotes 1998a)
T444 549-594 Sentence denotes Chemokines Tat1–86 No Morphine • ↑ CCL5, CCL2
T445 595-626 Sentence denotes • ↑ [Ca2+]i (Beclin1 dependent)
T446 627-683 Sentence denotes • ↓ Autophagy Mouse, primary mixed glia (Lapierre et al.
T447 684-689 Sentence denotes 2018)
T448 690-752 Sentence denotes HIVSF162 (R5) No Morphine • ↑ HIV-1 Tat-induced LTR expression
T449 753-817 Sentence denotes • ↑ CCR5 expression (inhibited by bivalent ligand in astrocytes)
T450 818-826 Sentence denotes • ↑ IL-6
T451 827-877 Sentence denotes • ↑ CCL5 Human, primary mixed glia (El-Hage et al.
T452 878-883 Sentence denotes 2013)
T453 884-1068 Sentence denotes Glial restricted precursors: survival & MOR, DOR, KOR expression Tat1–72 No Morphine (acting via DOR and/or KOR) • ↑ Caspase-3 activation & ↑ cell death by Tat or morphine via DOR, KOR
T454 1069-1142 Sentence denotes • No opioid-Tat interactions Mouse, primary glial precursors (Buch et al.
T455 1143-1148 Sentence denotes 2007)
T456 1149-1172 Sentence denotes MOR expression in NPCs;
T457 1173-1263 Sentence denotes NPC survival and developmental fate Tat1–72 No Morphine • MOR expressed by subsets of NPCs
T458 1264-1346 Sentence denotes • ↑ Astrocyte and immature glial death Mouse, primary mixed glia (Khurdayan et al.
T459 1347-1352 Sentence denotes 2004)
T460 1353-1535 Sentence denotes MOR and CCR5 interactions Tat1–86 (from HIVIIIB) No Morphine • ↓ Neuronal survival via CCR5 activation in glia (rescued by BDNF treatment) Mouse, primary neurons and glia (Kim et al.
T461 1536-1541 Sentence denotes 2018)
T462 1542-1605 Sentence denotes HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine
T463 1606-1728 Sentence denotes CCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine
T464 1729-1889 Sentence denotes • MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al.
T465 1890-1909 Sentence denotes 2013; Arnatt et al.
T466 1910-1915 Sentence denotes 2016)
T467 1916-2063 Sentence denotes HIV expression and maturational fate of neurons and astroglia HIVBaL (R5) No Morphine • ↑ HIV p24 and ↑ Tat mRNA levels with morphine after 21 days
T468 2064-2191 Sentence denotes • ↓ Proliferation of neural progenitors; ↑ astroglial and ↑ neuronal differentiation Human, neural progenitors (Balinang et al.
T469 2192-2197 Sentence denotes 2017)
T470 2198-2208 Sentence denotes Astrocytes
T471 2209-2261 Sentence denotes HIV expression HIVSF162 (R5) No Morphine • ↑ HIV p24
T472 2262-2314 Sentence denotes • ↑ CCL2 Human, primary astrocytes (Rodriguez et al.
T473 2315-2320 Sentence denotes 2017)
T474 2321-2375 Sentence denotes Toll-like receptor (TLR) expression/function • Tat1–72
T475 2376-2436 Sentence denotes • gp120 No Morphine • ↑ TLR2 with Tat, Tat + morphine, gp120
T476 2437-2513 Sentence denotes • ↓ TLR9 with Tat, morphine, gp120 Mouse, primary astrocytes (El-Hage et al.
T477 2514-2520 Sentence denotes 2011a)
T478 2521-2566 Sentence denotes Chemokines Tat1–72 No Morphine • ↑ CCL5, CCL2
T479 2567-2575 Sentence denotes • ↑ IL-6
T480 2576-2629 Sentence denotes • ↑ [Ca2+]i Mouse, primary astrocytes (El-Hage et al.
T481 2630-2635 Sentence denotes 2005)
T482 2636-2664 Sentence denotes Tat1–72 No Morphine • ↑ CCL2
T483 2665-2673 Sentence denotes • ↑ CCL5
T484 2674-2740 Sentence denotes • ↑ Microglial migration Mouse, primary astrocytes (El-Hage et al.
T485 2741-2747 Sentence denotes 2006a)
T486 2748-2793 Sentence denotes Tat1–72 No Morphine • ↑ CCL2, ↑ IL-6, ↑ TNF-α
T487 2794-2805 Sentence denotes • ↑ [Ca2+]i
T488 2806-2845 Sentence denotes • ↑ NF-κB trafficking and transcription
T489 2846-2933 Sentence denotes • No interaction / acceleration with morphine Mouse, primary astrocytes (El-Hage et al.
T490 2934-2940 Sentence denotes 2008b)
T491 2941-2971 Sentence denotes Tat No • U50,488 (KOR agonist)
T492 2972-3015 Sentence denotes • Nor-BNI (KOR antagonist) • U50,488 ↓ CCL2
T493 3016-3073 Sentence denotes • U50,488 ↓ NF-κB Human, primary astrocytes (Sheng et al.
T494 3074-3079 Sentence denotes 2003)
T495 3080-3117 Sentence denotes N/A No Morphine • ↑ CCR5, CCR3, CXCR2
T496 3118-3201 Sentence denotes • ↓ IL-8, CCL4 Human, astrocytoma U87 cell line, primary astrocytes (Mahajan et al.
T497 3202-3207 Sentence denotes 2002)
T498 3208-3217 Sentence denotes • Tat1–86
T499 3218-3361 Sentence denotes • gp120IIIB No Morphine Regional differences in cytokine and ROS production —differed for each insult Mouse, primary astrocytes (Fitting et al.
T500 3362-3368 Sentence denotes 2010a)
T501 3369-3413 Sentence denotes Oxidative stress / damage Tat1–72 No • DPDPE
T502 3414-3422 Sentence denotes • SNC-80
T503 3423-3537 Sentence denotes (DOR agonists) DOR agonists ↓ Tat-induced oxidative stress Human derived brain cell line (SK-N-SH) (Wallace et al.
T504 3538-3543 Sentence denotes 2006)
T505 3544-3588 Sentence denotes Inflammation, maturation /plasticity • Tat86
T506 3589-3750 Sentence denotes • Tat101 No Morphine ↓ β-catenin signaling and variably decreases TrkB, BDNF, and NLRP1 mRNA in fetal astrocytes b Human, U87MG and fetal astrocytes (Chen et al.
T507 3751-3756 Sentence denotes 2020)
T508 3757-3766 Sentence denotes Microglia
T509 3767-3815 Sentence denotes HIV replication HIVSF162 (R5) No • Endomorphin-1
T510 3816-3831 Sentence denotes • Endomorphin-2
T511 3832-3900 Sentence denotes (MOR agonists) • ↑ HIV p24 with endomorphin-1, but not endomorphin-2
T512 3901-3990 Sentence denotes • Endomorphin-1 acts via MOR, but not DOR / KOR Human, primary microglia (Peterson et al.
T513 3991-3996 Sentence denotes 1999)
T514 3997-4073 Sentence denotes HIVSF162 (R5) No Morphine ↑ HIV p24 Human, primary microglia (El-Hage et al.
T515 4074-4079 Sentence denotes 2014)
T516 4080-4130 Sentence denotes HIVSF162 (R5) No • U50,488; U69,593 (KOR agonists)
T517 4131-4196 Sentence denotes • Dynorphin Al-13 ↓ HIV p24 Human, primary microglia (Chao et al.
T518 4197-4203 Sentence denotes 1996b)
T519 4204-4219 Sentence denotes • HIVJR-FL (R5)
T520 4220-4261 Sentence denotes • gp120 No β-endorphin • ↑ HIV expression
T521 4262-4297 Sentence denotes • ↑ HIV p24 (14-day post infection)
T522 4298-4361 Sentence denotes • gp120 ↑ IL-1, TNF, IL-6 Human, fetal microglia (Sundar et al.
T523 4362-4367 Sentence denotes 1995)
T524 4368-4411 Sentence denotes HIVSF162 No • 8-CAC, U50,488 (KOR agonists)
T525 4412-4469 Sentence denotes • Cocaine • KOR agonist ↓ p24; blocked by KOR antagonists
T526 4470-4557 Sentence denotes • KOR agonist negates cocaine-induced ↑ HIV Human, fetal brain microglia (Gekker et al.
T527 4558-4563 Sentence denotes 2004)
T528 4564-4591 Sentence denotes HIVSF162 No OPRL1 antisense
T529 4592-4668 Sentence denotes Nociceptin / orphanin FQ (OPRL1 agonist) • OPRL1 antisense (and sense) ↓ p24
T530 4669-4764 Sentence denotes • Nociceptin, no effect on p24 Human, fetal brain microglia and mixed neurons/glia (Chao et al.
T531 4765-4771 Sentence denotes 1998b)
T532 4772-4797 Sentence denotes HIV expression • HIVSF162
T533 4798-4860 Sentence denotes • Tat ZDV U50,488 (KOR agonist) • ↓ p24 on day 14 with U50,488
T534 4861-4888 Sentence denotes • ↓ Neurotoxicity (U50,488)
T535 4889-4970 Sentence denotes • ↓ Quinolinate by microglia Human, fetal microglia and neural cells (Chao et al.
T536 4971-4976 Sentence denotes 2000)
T537 4977-5030 Sentence denotes Chemokines and Cytokines Tat1–72 No Morphine • ↑ CCR5
T538 5031-5048 Sentence denotes • ↑ CD11b, ↑ CD40
T539 5049-5075 Sentence denotes • ↑ TNF-α, ↑ IL-6, ↑ IP-10
T540 5076-5134 Sentence denotes • ↑ iNOS Mouse, BV-2 and primary microglia (Bokhari et al.
T541 5135-5140 Sentence denotes 2009)
T542 5141-5198 Sentence denotes MOR signaling Tat1–72 No Morphine • ↑ MOR (intracellular)
T543 5199-5267 Sentence denotes • ↑ MOR mRNA Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T544 5268-5273 Sentence denotes 2008)
T545 5274-5350 Sentence denotes Oxidative Stress Tat1–72 No Morphine • ↑ ROS [O2− (DHE), ↑ HO2•, H2O2 (DCF)]
T546 5351-5428 Sentence denotes • ↑ Protein carbonyls Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T547 5429-5434 Sentence denotes 2009)
T548 5435-5590 Sentence denotes Glutamate release Tat1–72 No Morphine ↑ Glutamate release via ↑ xc− cystine-glutamate antiporter expression/function Mouse, primary microglia (Gupta et al.
T549 5591-5596 Sentence denotes 2010)
T550 5597-5604 Sentence denotes Neurons
T551 5605-5711 Sentence denotes HIV expression HIV No Morphine ↑ HIV expression Human derived, SH-SY5Y neuroblastoma cells (Squinto et al.
T552 5712-5717 Sentence denotes 1990)
T553 5718-5773 Sentence denotes Homeostasis and Injury Tat1–86 No Morphine • ↑ [Ca2+]i,
T554 5774-5784 Sentence denotes • ↑ [Na+]i
T555 5785-5820 Sentence denotes • ↓ ΔΨm (mitochondrial) instability
T556 5821-5886 Sentence denotes • ↑ Dendritic degeneration Mouse, primary neurons (Fitting et al.
T557 5887-5893 Sentence denotes 2014a)
T558 5894-5959 Sentence denotes Mitochondrial inner membrane potential and ROS • Tat1–86, Tat1–72
T559 5960-6234 Sentence denotes • gp120 No Morphine ↑ ΔΨm instability and oxidative stress ↑ with Tat + morphine, ↑ neuroprotection with allopregnanolone Human, primary neurons ; mouse, striatal medium spiny neurons; mouse, striatal medium spiny neurons, SH-SY5Y neuroblastoma cells (Turchan-Cholewo et al.
T560 6235-6253 Sentence denotes 2006; Paris et al.
T561 6254-6259 Sentence denotes 2020)
T562 6260-6375 Sentence denotes Neuronal survival Tat1–86 No Morphine • ↓ Neuronal survival from Tat + morphine and ↓ glial CX3CL1 rescued by CX3CL
T563 6376-6481 Sentence denotes • CX3CL1 (fractalkine) regulates microglial motility Mouse, primary neurons and mixed glia (Suzuki et al.
T564 6482-6487 Sentence denotes 2011)
T565 6488-6525 Sentence denotes Tat1–86 No Morphine • ↓ Proliferation
T566 6526-6547 Sentence denotes • ↑ ERK1/2 activation
T567 6548-6563 Sentence denotes • ↑ p53 and p21
T568 6564-6633 Sentence denotes • ↓ Cyclin D1 and Akt levels Human, neuronal precursors (Malik et al.
T569 6634-6639 Sentence denotes 2014)
T570 6640-6690 Sentence denotes Tat1–72, Tat1–86 No Morphine • ↓ Neuronal survival
T571 6691-6850 Sentence denotes • ↑ Neuronal survival with ibudilast (AV411) (inhibiting glial NF-κB blocks Tat ± morphine neurotoxicity) Mouse, primary neurons and mixed glia (Gurwell et al.
T572 6851-6871 Sentence denotes 2001; El-Hage et al.
T573 6872-6877 Sentence denotes 2014)
T574 6878-6917 Sentence denotes White matter/oligodendroglial pathology
T575 6918-7043 Sentence denotes Changes in OL survival and morphology Tat1–86 No Morphine (25 mg pellet, 7 days); morphine (in vitro) • ↑ Degeneration of OLs
T576 7044-7064 Sentence denotes • ↑ TUNEL reactivity
T577 7065-7131 Sentence denotes • ↑ Caspase-3 activation Mouse, Tat tg; primary OLs (Hauser et al.
T578 7132-7137 Sentence denotes 2009)
T579 7138-7184 Sentence denotes Blood-brain barrier and the neurovascular unit
T580 7185-7247 Sentence denotes BBB model integrity and function Tat1–86 No Morphine • ↑ TNF-α
T581 7248-7256 Sentence denotes • ↑ IL-8
T582 7257-7264 Sentence denotes • ↓TEER
T583 7265-7285 Sentence denotes • ↑ JAM-2 expression
T584 7286-7389 Sentence denotes • ↑ Monocyte transmigration with CCL5 Human, using primary BMVEC and primary astrocytes (Mahajan et al.
T585 7390-7395 Sentence denotes 2008)
T586 7396-7424 Sentence denotes ARV accumulation Tat1–86 DTG
T587 7425-7428 Sentence denotes FTC
T588 7429-7518 Sentence denotes TFV Morphine • ↓ Intracellular ARV concentrations Human, primary astrocytes (Patel et al.
T589 7519-7524 Sentence denotes 2019)
T590 7525-7549 Sentence denotes HIV-1 strain differences
T591 7550-7646 Sentence denotes Neuronal Survival Tat1–86 (clades B & C) No Morphine • ↓ Neuronal survival via MOR on mixed glia
T592 7647-7668 Sentence denotes • ↑ ROS in astrocytes
T593 7669-7760 Sentence denotes • ↑ Iba1 and 3-NT microglia with morphine Mouse, primary neurons and mixed glia (Zou et al.
T594 7761-7766 Sentence denotes 2011)
T595 7767-7778 Sentence denotes • gp120IIIB
T596 7779-7793 Sentence denotes • gp120MN (X4)
T597 7794-8017 Sentence denotes • gp120ADA (R5) No Morphine ↓ Neuronal survival in presence of glia with gp120MN and transiently with gp120IIIB (X4), not R5-tropic gp120, in combination with morphine Mouse, primary neurons and mixed glia (Podhaizer et al.
T598 8018-8023 Sentence denotes 2012)
T599 8024-8117 Sentence denotes Proliferation and maturational fate of neural progenitors and oligodendroglia • HIVSF162 (R5)
T600 8118-8220 Sentence denotes • HIVIIIB (X4) No Morphine • ↓ Proliferation of immature neural and OL progenitors with Tat + morphine
T601 8221-8272 Sentence denotes • ↓ NPC DNA synthesis with R5-tropic HIV + morphine
T602 8273-8393 Sentence denotes • ↑ NPC DNA synthesis with X4-tropic HIV + morphine Mouse, Tat tg; Mouse, Human, primary neural progenitors (Hahn et al.
T603 8394-8399 Sentence denotes 2012)
T604 8400-8427 Sentence denotes GABA function • HIVBaL (R5)
T605 8428-8455 Sentence denotes • gp120 (ADA, MN, and IIIB)
T606 8456-8518 Sentence denotes • Tat1–86 No Morphine • Tat or morphine ↓ KCC2 levels via CCR5
T607 8519-8648 Sentence denotes • ↑ KCC2 prevents Tat and R5 HIV, gp120, but not X4, gp120 neurotoxicity ± morphine Human, primary neurons, hNPCs (Barbour et al.
T608 8649-8654 Sentence denotes 2020)
T609 8655-8707 Sentence denotes Astroglial CCL5 and neuroprotection • gp120IIIB (X4)
T610 8708-8745 Sentence denotes • gp120BaL (R5) No • Morphine (10 μM)
T611 8746-8814 Sentence denotes • DAMGO • Morphine ↑ astroglial CCL5 blocking gp120BaL neurotoxicity
T612 8815-8966 Sentence denotes • Morphine (or CXCL12) does not block gp120IIIB neurotoxicity Rat, mixed neurons and glia; isolated neurons, astrocytes and microglia (Avdoshina et al.
T613 8967-8972 Sentence denotes 2010)
T614 8973-9066 Sentence denotes aassumed Clade B, unless noted otherwise, b statistical findings for some results are unclear
T615 9067-9977 Sentence denotes ARV, antiretroviral(s); BMVEC, brain vascular endothelial cells; [Ca2+]i intracellular calcium concentration; 8-CAC, 8-carboxamidocyclazocine; DAMGO, D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DCF, dihydro-dichlorofluorescein; DOR, δ-opioid receptor; DHE, dihydroethidium; DTG, dolutegravir; DPDPE, [D-Pen2,D-Pen5]enkephalin; FTC, emtricitabine; GABA, γ-aminobutyric acid; Iba1, ionized calcium-binding adapter molecule 1; JAM-1, junctional adhesion molecule-1; KCC2, K+-Cl− cotransporter 2; KOR, κ-opioid receptor; LTR, long terminal repeat; ΔΨm, mitochondrial inner membrane potential; MOR, μ-opioid receptor; [Na+]i, intracellular sodium concentration; nor-BNI, nor-binaltorphimine; NPCs, neural progenitor cells; OLs, oligodendroglia; ROS, reactive oxygen species; TEER, transendothelial electrical resistance; TFV, tenofovir; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; ZDV, zidovudine
T616 9978-10127 Sentence denotes For practicality, the table is limited to key studies in the CNS with emphasis on neuropathological or neuroimmune rather than psychosocial outcomes.
T617 10128-10535 Sentence denotes With deference toward the excellent studies we excluded: (1) on opioid and HIV effects on PBMCs, or on isolated lymphocytes and monocytes, not directly related to the central nervous system or BBB; (2) on HIV or opioid and ARV interactions in the peripheral nervous system; and (3) studies not directly examining opioid-HIV interactions (irrespective of whether a positive or negative interaction was found)