PMC:7463108 / 110421-111201 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1377 0-170 Sentence denotes Another study measured intracellular concentrations of dolutegravir, tenofovir and emtricitabine in primary human astrocytes, microglia, pericytes and BMECs (Patel et al.
T1378 171-177 Sentence denotes 2019).
T1379 178-291 Sentence denotes Intracellular ARV concentrations were typically significantly higher in BMECs than in the other brain cell types.
T1380 292-426 Sentence denotes Dolutegravir achieved the highest relative concentrations within each cell type, whereas tenofovir accumulated the least (Patel et al.
T1381 427-433 Sentence denotes 2019).
T1382 434-583 Sentence denotes Furthermore, 24 h treatment with morphine significantly decreased intracellular accumulation of composite ARV concentrations, but only in astrocytes.
T1383 584-703 Sentence denotes In contrast, morphine exposure significantly increased the net accumulation of drugs within BMECs compared to controls.
T1384 704-773 Sentence denotes BMECs may sequester ARV drugs as a protective mechanism (Patel et al.
T1385 774-780 Sentence denotes 2019).