LitCovid-sentences  

PMC:7463108 / 105713-107502 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1330 0-108 Sentence denotes There are several known drug-drug interactions between opioids and ARVs that affect systemic concentrations.
T1331 109-214 Sentence denotes The partial opioid agonist, buprenorphine, is metabolized primarily by cytochrome P450 (CYP) 3A4 and 2C8.
T1332 215-365 Sentence denotes Both buprenorphine and its active metabolite, norbuprenorphine, are glucuronidated by UDP-glucuronosyltransferase (UGT) 1A1 and then excreted in bile.
T1333 366-422 Sentence denotes Several ARVs inhibit or induce these metabolic pathways.
T1334 423-477 Sentence denotes However, not all interactions are clinically relevant.
T1335 478-779 Sentence denotes The boosted protease inhibitor combination, atazanavir/ritonavir, inhibits CYP 3A4 and UGT 1A1, leading to increases in overall systemic exposure of buprenorphine and norbuprenorphine and also results in symptoms of opioid excess, such as increased sedation and impaired cognition (McCance-Katz et al.
T1336 780-786 Sentence denotes 2007).
T1337 787-912 Sentence denotes Dose adjustments of buprenorphine are recommended when initiating therapy with atazanavir to avoid symptoms of opioid excess.
T1338 913-1027 Sentence denotes Methadone is a full opioid substrate with multiple metabolic pathways, including CYP 3A4, 2B6, 2C19, 2C9, and 2D6.
T1339 1028-1120 Sentence denotes Several pharmacokinetic interactions are reported between methadone and protease inhibitors.
T1340 1121-1225 Sentence denotes However, withdrawal symptoms are rare, and therefore, dose adjustments are not recommended (Bruce et al.
T1341 1226-1246 Sentence denotes 2006; Meemken et al.
T1342 1247-1253 Sentence denotes 2015).
T1343 1254-1418 Sentence denotes In contrast, efavirenz and nevirapine induce CYP 3A4, resulting in decreased systemic concentrations of methadone and the development of opioid withdrawal symptoms.
T1344 1419-1563 Sentence denotes To avoid opioid withdrawal, increased methadone dosing is recommended when either efavirenz or nevirapine therapy is initiated (Marzolini et al.
T1345 1564-1583 Sentence denotes 2000; Clarke et al.
T1346 1584-1604 Sentence denotes 2001; Meemken et al.
T1347 1605-1611 Sentence denotes 2015).
T1348 1612-1764 Sentence denotes Oxycodone metabolism is inhibited by lopinavir/ritonavir, increasing oxycodone concentrations as well as the self-reported drug effects (Nieminen et al.
T1349 1765-1782 Sentence denotes 2010; Feng et al.
T1350 1783-1789 Sentence denotes 2017).