LitCovid-sentences  

PMC:7463108 / 10204-11969 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T106 0-140 Sentence denotes Preclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al.
T107 141-164 Sentence denotes 2006; Hutchinson et al.
T108 165-177 Sentence denotes 2008, 2009).
T109 178-343 Sentence denotes Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al.
T110 344-350 Sentence denotes 2006).
T111 351-512 Sentence denotes Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al.
T112 513-536 Sentence denotes 2006; Hutchinson et al.
T113 537-553 Sentence denotes 2009; Liu et al.
T114 554-708 Sentence denotes 2010). μ (MOR), δ (DOR), and κ (KOR) opioid receptors are expressed by subsets of astrocytes and microglia (Stiene-Martin and Hauser 1991; Eriksson et al.
T115 709-735 Sentence denotes 1992; Stiene-Martin et al.
T116 736-756 Sentence denotes 1993; Ruzicka et al.
T117 757-777 Sentence denotes 1995; Gurwell et al.
T118 778-797 Sentence denotes 1993; Hauser et al.
T119 798-826 Sentence denotes 1996; Turchan-Cholewo et al.
T120 827-846 Sentence denotes 2008; Maduna et al.
T121 847-1010 Sentence denotes 2018) and are involved in opioid tolerance and dependence to varying degrees (Kieffer and Gaveriaux-Ruff 2002; Berger and Whistler 2010; Morgan and Christie 2011).
T122 1011-1123 Sentence denotes Despite some reports of morphine triggering immune activation via Toll-like receptor 4 (TLR4) (Terashvili et al.
T123 1124-1147 Sentence denotes 2008; Hutchinson et al.
T124 1148-1199 Sentence denotes 2010; Coller and Hutchinson 2012; Hutchinson et al.
T125 1200-1221 Sentence denotes 2012; Theberge et al.
T126 1222-1244 Sentence denotes 2013; Lacagnina et al.
T127 1245-1326 Sentence denotes 2017) by binding to a myeloid differentiation protein-2 intermediary (Wang et al.
T128 1327-1521 Sentence denotes 2012), this is contrary to the typical actions of opiates, which by themselves (and in the absence of a priming event such as HIV co-exposure) tend to suppress immune function (Eisenstein 2019).
T129 1522-1676 Sentence denotes A vast majority of the immune, antinociceptive, and other physiological effects of opioids are mediated by opioid receptors per se and not TLR4 (Hu et al.
T130 1677-1698 Sentence denotes 2011; Fukagawa et al.
T131 1699-1719 Sentence denotes 2013; Stevens et al.
T132 1720-1741 Sentence denotes 2013; Mattioli et al.
T133 1742-1765 Sentence denotes 2014; Eisenstein 2019).