LitCovid-sentences  

PMC:7463108 / 100234-105195 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1266 0-95 Sentence denotes Opioid Substitution Therapies and the Role of Selective/Biased Agonism in neuroHIV Pathogenesis
T1267 96-397 Sentence denotes Although morphine, methadone, and buprenorphine all activate MOR, each can impart different signals through MOR, related to the nature and timing of their coupling to Gα, Gβγ, β-arrestin and/or regulators of G protein signaling (RGS), since each downstream effector couples into unique cell functions.
T1268 398-539 Sentence denotes Functional selectivity occurs at each opioid receptor type, and for most endogenous opioid peptides at all three receptor types (Gomes et al.
T1269 540-546 Sentence denotes 2020).
T1270 547-771 Sentence denotes Moreover, opioid receptors can be expressed on a subset of virtually every cell type in the CNS—with second messenger coupling to each opioid receptor type potentially being unique, cell-type specific, and context dependent.
T1271 772-861 Sentence denotes Thus, the “pluridimensional” (Galandrin and Bouvier 2006; Kenakin 2011; Costa-Neto et al.
T1272 862-1096 Sentence denotes 2016) actions of any opiate at MOR are sufficiently complicated that it is not possible to predict whether, e.g., morphine, methadone or buprenorphine, would similarly effect any aspect of neuroHIV pathology without empirical testing.
T1273 1097-1338 Sentence denotes Despite their significant use as medication-assisted therapies for treating opioid addiction, few studies have directly compared commonly used opiate substitution therapies (Bell and Strang 2020), especially in relation to HIV (Khalsa et al.
T1274 1339-1356 Sentence denotes 2006; Choi et al.
T1275 1357-1363 Sentence denotes 2020).
T1276 1364-1493 Sentence denotes Opioid substitution therapies significantly reduce the frequency of injection drug use (Kwiatkowski and Booth 2001; Pettes et al.
T1277 1494-1549 Sentence denotes 2010), decrease HIV transmission risk (MacArthur et al.
T1278 1550-1568 Sentence denotes 2012; Platt et al.
T1279 1569-1625 Sentence denotes 2016), and reduce drug-related mortality (Mathers et al.
T1280 1626-1678 Sentence denotes 2013) and the risk of opioid overdose (Volkow et al.
T1281 1679-1685 Sentence denotes 2014).
T1282 1686-1886 Sentence denotes Further, improved ARV outcomes among PWH have been reported with opioid substitution therapies, including the uptake and retention on ARV, medication adherence rates, and viral suppression (Low et al.
T1283 1887-1911 Sentence denotes 2016; Mukandavire et al.
T1284 1912-1918 Sentence denotes 2017).
T1285 1919-2114 Sentence denotes The two main medications used for opioid substitution therapy include methadone, a MOR full agonist, and buprenorphine, a MOR partial agonist and partial antagonist of KOR (Noble and Marie 2018).
T1286 2115-2395 Sentence denotes In comparison to methadone, buprenorphine has been shown to have fewer pharmacodynamic interactions with ARVs and causes less opioid withdrawal symptoms potentially due to its partial agonism on MOR, but also due to its high affinity and long duration of MOR binding (Walsh et al.
T1287 2396-2445 Sentence denotes 1994; McCance-Katz 2005; Whelan and Remski 2012).
T1288 2446-2567 Sentence denotes Further, differential proinflammatory and neurotoxic effects have been noted for various opioid treatments (Boland et al.
T1289 2568-2588 Sentence denotes 2014; Fitting et al.
T1290 2589-2611 Sentence denotes 2014b; Carvallo et al.
T1291 2612-2638 Sentence denotes 2015; Dutta and Roy 2015).
T1292 2639-2743 Sentence denotes In primary astrocytes, agonist-selective actions at MOR and KOR can be clearly demonstrated (Bohn et al.
T1293 2744-2765 Sentence denotes 2000; Belcheva et al.
T1294 2766-2787 Sentence denotes 2003; McLennan et al.
T1295 2788-2805 Sentence denotes 2008; Hahn et al.
T1296 2806-2960 Sentence denotes 2010), and we found that morphine, methadone, and buprenorphine differentially increase ROS and [Ca2+]i alone or following Tat co-exposure (Fitting et al.
T1297 2961-2968 Sentence denotes 2014b).
T1298 2969-3071 Sentence denotes Morphine can enhance HIV-1-induced production of cytokines and specifically chemokines (El-Hage et al.
T1299 3072-3104 Sentence denotes 2008a; Dave 2012; El-Hage et al.
T1300 3105-3270 Sentence denotes 2014), while other opioids including methadone, oxycodone, buprenorphine, and DAMGO can decrease inflammatory function and decrease monocyte migration (Boland et al.
T1301 3271-3292 Sentence denotes 2014; Carvallo et al.
T1302 3293-3325 Sentence denotes 2015; Jaureguiberry-Bravo et al.
T1303 3326-3347 Sentence denotes 2016; Chilunda et al.
T1304 3348-3354 Sentence denotes 2019).
T1305 3355-3657 Sentence denotes As most opiate drugs preferentially act via MOR, a potential explanation for differential interactive effects of opioids in the context of neuroHIV is the phenomenon of selective or “biased agonism”, such that different agonists can trigger distinct signaling events at the same receptor (Hauser et al.
T1306 3658-3664 Sentence denotes 2012).
T1307 3665-3806 Sentence denotes For example, coupling of MOR to Gα, Gβγ, and/or β-arrestin have been noted to differ depending on the MOR agonists involved (McPherson et al.
T1308 3807-3828 Sentence denotes 2010; Thompson et al.
T1309 3829-3850 Sentence denotes 2015; Burgueno et al.
T1310 3851-3857 Sentence denotes 2017).
T1311 3858-4060 Sentence denotes Physiologic outcomes of MOR activation in any cell type are determined by a bias for specific signaling pathways, the initial step of which is activation of G proteins and/or β-arrestin (Williams et al.
T1312 4061-4081 Sentence denotes 2013b; Violin et al.
T1313 4082-4105 Sentence denotes 2014; Suomivuori et al.
T1314 4106-4112 Sentence denotes 2020).
T1315 4113-4282 Sentence denotes The subcellular organization of GPCR signaling transduced by heterotrimeric G proteins and β-arrestin has been recently reviewed in detail (Eichel and von Zastrow 2018).
T1316 4283-4481 Sentence denotes In the context of HIV, it has been shown that selective MOR agonists such as endomorphin-1, but not DAMGO or morphine, significantly increase HIV-1 replication in infected microglia (Peterson et al.
T1317 4482-4488 Sentence denotes 1999).
T1318 4489-4706 Sentence denotes This effect might be due to an apparent bias of endomorphin-1 towards arrestin recruitment and receptor phosphorylation, which was significantly correlated with agonist-induced internalization of MOR (McPherson et al.
T1319 4707-4713 Sentence denotes 2010).
T1320 4714-4954 Sentence denotes It is suggested that ligands that display bias towards G protein-mediated pathways and away from β-arrestin 2 recruitment may have improved therapeutic profiles against the development of tolerance and dependence/addiction (McPherson et al.
T1321 4955-4961 Sentence denotes 2010).