| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T680 |
0-70 |
Sentence |
denotes |
Further SARs of 159 and 165 were investigated to improve the activity. |
| T681 |
71-210 |
Sentence |
denotes |
However, no significant improvement in the activity was observed for the prepared compounds either in the enzymatic or cell‐based bioassay. |
| T682 |
211-282 |
Sentence |
denotes |
Compounds 167–169 (Figure 36) displayed the best inhibitory activities. |
| T683 |
283-425 |
Sentence |
denotes |
Especially, the m‐fluoro‐substituted benzamide derivative 168 (IC50, 0.15 µM; EC50, 5.4 µM) showed the best inhibition activity against PLpro. |
| T684 |
426-482 |
Sentence |
denotes |
It also inhibited SARS‐CoV‐1 in the cell‐based bioassay. |
| T685 |
483-562 |
Sentence |
denotes |
Both compounds 168 and 169 were metabolically more stable when compared to 167. |
