| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T675 |
0-63 |
Sentence |
denotes |
Next, the same group studied the SARs for compound 158 further. |
| T676 |
64-224 |
Sentence |
denotes |
This led to the discovery of compound 165 with high PLpro inhibitory activity of SARS‐CoV‐1 (IC50, 0.32 µM) and antiviral activity (EC50, 9.1 µM) in Vero cells. |
| T677 |
225-319 |
Sentence |
denotes |
199 The mode of action of 165 was found to be a noncovalent, competitive inhibition of PLpro. |
| T678 |
320-451 |
Sentence |
denotes |
Unlike the previous series, the stereochemistry at the α‐methyl group did not make a significant difference in inhibition of PLpro. |
| T679 |
452-661 |
Sentence |
denotes |
For example, both (S)‐ and (R)‐methyl inhibitors, 165 (IC50, 0.32 µM; EC50, 9.1 µM and 166 (IC50, 0.56 µM; EC50, 9.1 µM), respectively, shared equipotent inhibitory activity in enzymatic and cell‐based assays. |
