PMC:7461420 / 73830-74386 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T638 74-171 Sentence denotes Among them, the two best compounds 147 and 148 display IC50 values of 0.3 and 3 µM, respectively.
T639 172-289 Sentence denotes A variety of SARS‐CoV‐1 Mpro inhibitors have been identified through virtual screening (VS) as an alternative to HTS.
T640 290-404 Sentence denotes VS of 50 240 structurally diverse small molecules allowed to identify 104 molecules with anti‐SARS‐CoV‐1 activity.
T641 405-556 Sentence denotes Compound 149 (Figure 34) demonstrated potent enzyme inhibition (IC50, 2.5 μM) and an EC50 of 7 μM in Vero cell‐based SARS‐CoV‐1 plaque reduction assays