PMC:7461420 / 66288-67250 JSON TXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T574	0-97	Sentence	denotes	Previously, isatin (2,3‐dioxoindole) derivatives were observed to inhibit rhinovirus 3C protease.
T575	98-246	Sentence	denotes	176 Due to the structural similarity between the rhinovirus 3C protease and SARS‐CoV‐1 Mpro, these derivatives were tested against SARS‐CoV‐1 Mpro.
T576	247-386	Sentence	denotes	Among them, 106 (IC50, 0.95 µM) and 107 (IC50, 0.98 µM) exhibited the best SARS‐CoV‐1 Mpro inhibitory activity in the low micromolar range.
T577	387-545	Sentence	denotes	176 SAR studies suggested that the inhibition efficiency was mainly reliant on hydrophobic and electronic properties of the isatin core substitution pattern.
T578	546-634	Sentence	denotes	Docking studies revealed that the molecules fit well in the active site of the protease.
T579	635-739	Sentence	denotes	Both carbonyl groups of the isatin core engaged in H‐bonds with NH of Gly143, Ser144, Cys145, and His41.
T580	740-962	Sentence	denotes	Compounds 106 and 107 176 were more selective for SARS‐CoV‐1 Mpro than other proteases like papain (106, 103 µM; 107, 87.24 µM), chymotrypsin (106, ~1 mM; 107, 10.4 µM), and trypsin (106, 362 µM; 107, 243 µM; Figure 28).