| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T473 |
0-142 |
Sentence |
denotes |
Due to the high similarity between SARS‐CoV‐1 Mpro and SARS‐CoV‐2 Mpro authors speculated that 64 was likely to inhibit the new virus as well. |
| T474 |
143-249 |
Sentence |
denotes |
Zhang et al. recently reported this molecule as a SARS‐CoV‐2 Mpro inhibitor with an IC50 value of 0.18 µM. |
| T475 |
250-423 |
Sentence |
denotes |
They first resolved the unliganded crystal structure of SARS‐CoV‐2 Mpro (Figure 20), 157 which is largely identical to that of SARS‐CoV‐1 Mpro with a 96% sequence identity. |
| T476 |
424-565 |
Sentence |
denotes |
Compound 64 was docked to SARS‐CoV‐2 Mpro, and a series of structural modifications were performed to improve its pharmacokinetic properties. |
| T477 |
566-822 |
Sentence |
denotes |
Specifically, masking the P2‐P3 amide bond with the pyridone ring could improve plasma half‐life; and exchanging the lipophilic cinnamoyl residue for the less lipophilic Boc group, could increase plasma solubility and reduce its binding to plasma proteins. |
