PMC:7461420 / 52803-53453 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T470 197-386 Sentence denotes As a result, the replacement of P2‐phenyl with P2‐cyclohexyl (64) was found to be the best substitution, while P2‐cyclopentyl (65) showed similar potency against the enzyme SARS‐CoV‐1 Mpro.
T471 387-546 Sentence denotes In Huh7 cells, 64 also showed strong antiviral activity with an EC50 of 400 pM, but in Vero cells the antiviral activity of 64 was drastically reduced to 5 µM.
T472 547-650 Sentence denotes This compound also exhibited antiviral activity against a range of enteroviruses in various cell lines.