| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T451 |
0-148 |
Sentence |
denotes |
Azapeptide epoxides (APEs) are another class of SARS‐CoV‐1 Mpro inhibitors, although they were originally developed for clan CD cysteine peptidases. |
| T452 |
149-300 |
Sentence |
denotes |
152 , 153 The epoxide S,S‐diastereomer 60 (K inact/K i, 1900 (±400) M−1·s−1; Figure 17) exhibited the best inhibitory activity against SARS‐CoV Mpro. |
| T453 |
301-444 |
Sentence |
denotes |
154 The X‐ray structure of Mpro in complex with 60 confirmed the formation of a covalent bond between the cysteine‐S atom and the epoxide C‐3. |
| T454 |
445-525 |
Sentence |
denotes |
It is worth noting that the S,S‐configured epoxide is required for the activity. |
