| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T410 |
0-132 |
Sentence |
denotes |
Based on the highly potent 1,4‐Michael‐acceptor‐based inhibitor 38, which they had previously developed (see Figure 15), Yang et al. |
| T411 |
133-228 |
Sentence |
denotes |
134 designed a peptide with a new efficient cysteine‐reactive group, using an aldehyde moiety. |
| T412 |
229-382 |
Sentence |
denotes |
In addition, the P2‐leucine and the Michael groups of 38 were modified by a cyclohexyl unit and aldehyde group respectively to improve cellular activity. |
| T413 |
383-502 |
Sentence |
denotes |
Indeed, the resulting peptide‐aldehyde 41 (Figure 15) showed remarkable activity against SARS‐CoV‐1 and HCoV‐229E Mpro. |
| T414 |
503-648 |
Sentence |
denotes |
134 It displayed promising antiviral activities decreasing viral load by 4.7 log (at 5 µM) for SARS‐CoV‐1 and 5.2 log (at 1.2 µM) for HCoV‐229E. |
| T415 |
649-777 |
Sentence |
denotes |
This compound was stable in rat, mouse, and human plasma (even after 120 min, more than 70% of it remained in respective cells). |
