PMC:7461420 / 43028-43880 JSON TXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T393	0-70	Sentence	denotes	SARS‐CoV‐2 shares only 82% of its genome with its relative SARS‐CoV‐1.
T394	71-167	Sentence	denotes	However, essential viral enzymes of both species show sequence similarities of greater than 90%.
T395	168-287	Sentence	denotes	137 , 139 , 140 , 141 , 142 SARS‐CoV‐2 3CLpro is highly similar to SARS‐CoV‐1 3CLpro, sharing 96% of its sequence.
T396	288-383	Sentence	denotes	Therefore, one could expect that SARS‐CoV‐1 Mpro inhibitors are active against SARS‐CoV‐2 Mpro.
T397	384-539	Sentence	denotes	Compound 40 was found to be active against SARS‐CoV‐2 Mpro and its value of kobs/[I] for the COVID‐19 virus Mpro was determined to be 11 300 ± 880 M−1·s−1.
T398	540-632	Sentence	denotes	143 Peptide N3 was co‐crystalized with SARS‐CoV‐1 Mpro at 2.1 Å resolution (see Figure 13).
T399	633-723	Sentence	denotes	Its binding mode to SARS‐CoV‐2 Mpro is highly similar to that of other CoV main proteases.
T400	724-852	Sentence	denotes	Some key features include the Cys‐His catalytic dyad and the substrate‐binding pocket situated in a gap between domain I and II.