LitCovid-sentences  

PMC:7461420 / 100695-108554 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T889 0-36 Sentence denotes 6 Conclusions and future directions
T890 37-225 Sentence denotes The SARS‐CoV‐2 outbreak has caused worldwide disruption and was recently declared a global pandemic by the World Health Organization (WHO) owing to its rapid spread and high fatality rate.
T891 226-322 Sentence denotes As there is no effective treatment to date, the number of infections continues to rise globally.
T892 323-464 Sentence denotes This has led numerous research groups around the world to prioritize the identification and development of new therapeutics against COVID‐19.
T893 465-633 Sentence denotes Although it is often considered the most promising method to prevent or contain future coronavirus outbreaks, an all‐round anti‐CoV vaccine is possibly a long way away.
T894 634-730 Sentence denotes Small molecule drugs have the potential to be effective, rapidly produced, and widely available.
T895 731-950 Sentence denotes Indeed, several small molecules have been investigated and advanced to clinical trials for the treatment of COVID‐19, selected drug candidates are indicated in Table 3 (https://covid-19.heigit.org/clinical_trials.html).
T896 951-1036 Sentence denotes Table 3 Selection of molecules investigated in ongoing clinical studies (July, 2020)
T897 1037-1080 Sentence denotes Name Structure Description Recent trials
T898 1081-1138 Sentence denotes Azithromycin Macrolide antibiotic IRCT20200428047228N2
T899 1139-1150 Sentence denotes NCT04405921
T900 1151-1173 Sentence denotes EUCTR2020‐001605‐23‐ES
T901 1174-1230 Sentence denotes Favipiravir Broad spectrum antiviral drug NCT04434248
T902 1231-1247 Sentence denotes ChiCTR2000033491
T903 1248-1259 Sentence denotes NCT04425460
T904 1260-1321 Sentence denotes Triazavirin Broad‐spectrum antiviral drug ChiCTR2000030001
T905 1322-1371 Sentence denotes Umifenovir Antiviral drug IRCT20200523047550N1
T906 1372-1393 Sentence denotes IRCT20151227025726N15
T907 1394-1414 Sentence denotes IRCT20200325046859N2
T908 1415-1468 Sentence denotes Baloxavir marboxil Antiviral drug ChiCTR2000029548
T909 1469-1485 Sentence denotes ChiCTR2000029544
T910 1486-1526 Sentence denotes Remdesivir Antiviral drug NCT04431453
T911 1527-1538 Sentence denotes NCT04409262
T912 1539-1550 Sentence denotes NCT04410354
T913 1551-1599 Sentence denotes Ribavirin Antiviral drug IRCT20200324046850N2
T914 1600-1616 Sentence denotes ChiCTR2000030922
T915 1617-1683 Sentence denotes Lopinavir/ritonavir Anti‐HIV combination medication NCT04403100
T916 1684-1695 Sentence denotes NCT04376814
T917 1696-1747 Sentence denotes Celecoxib COX‐2 selective NSAID ChiCTR2000031630
T918 1748-1803 Sentence denotes Chloroquine Antimalarial drug EUCTR2020‐001441‐39‐IT
T919 1804-1815 Sentence denotes NCT04447534
T920 1816-1827 Sentence denotes NCT04443270
T921 1828-1890 Sentence denotes Hydroxychloroquine Antimalarial drug EUCTR2020‐001558‐23‐IT
T922 1891-1913 Sentence denotes EUCTR2020‐001441‐39‐IT
T923 1914-1936 Sentence denotes EUCTR2020‐001501‐24‐IT
T924 1937-1991 Sentence denotes Mefloquine Antimalarial drug EUCTR2020‐001194‐69‐ES
T925 1992-2051 Sentence denotes Ivermectin Broad‐spectrum antiparasitic drug NCT04445311
T926 2052-2063 Sentence denotes NCT04435587
T927 2064-2075 Sentence denotes NCT04431466
T928 2076-2139 Sentence denotes Colchicine Broad‐spectrum anti‐inflammatory drug NCT04416334
T929 2140-2162 Sentence denotes EUCTR2020‐001841‐38‐ES
T930 2163-2183 Sentence denotes IRCT20190810044500N5
T931 2184-2270 Sentence denotes Corticosteroids (misc.) Broad‐spectrum anti‐inflammatory drug IRCT20151227025726N17
T932 2271-2282 Sentence denotes NCT04395105
T933 2283-2305 Sentence denotes IRCT20120215009014N354
T934 2306-2378 Sentence denotes Pirfenidone Antifibrotic, anti‐inflammatory drug IRCT20200314046764N1
T935 2379-2395 Sentence denotes ChiCTR2000031138
T936 2396-2448 Sentence denotes Tranilast Anti‐inflammatory drug ChiCTR2000030002
T937 2449-2489 Sentence denotes Selinexor Anticancer drug NCT04355676
T938 2490-2501 Sentence denotes NCT04349098
T939 2502-2524 Sentence denotes EUCTR2020‐001411‐25‐GB
T940 2525-2585 Sentence denotes Valsartan Angiotensin II receptor antagonist DRKS00021732
T941 2586-2597 Sentence denotes NCT04335786
T942 2598-2652 Sentence denotes Dipyridamole PDE3 inhibitor NCT04424901 NCT04391179
T943 2653-2722 Sentence denotes Vidoflumidus (IMU‐838) Investigational drug EUCTR2020‐001264‐28‐HU
T944 2723-2777 Sentence denotes Azvudine Investigational antiviral ChiCTR2000032769
T945 2778-2789 Sentence denotes NCT04425772
T946 2790-2806 Sentence denotes ChiCTR2000030487
T947 2807-2857 Sentence denotes EIDD‐2801 Investigational antiviral NCT04405570
T948 2858-2869 Sentence denotes NCT04405739
T949 2870-2881 Sentence denotes NCT04392219
T950 2882-2905 Sentence denotes John Wiley & Sons, Ltd.
T951 2906-3030 Sentence denotes This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T952 3031-3213 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T953 3214-3397 Sentence denotes As outlined in this review, inhibitors of important viral enzymes or structures, such as Mpro, PLpro, or RdRP have displayed encouraging activity against various human‐infecting CoVs.
T954 3398-3666 Sentence denotes Since, both contagious viruses, SARS‐CoV‐1 and SARS‐CoV‐2, have a similar mechanism of infection; and both share the same human receptor, ACE2, for viral entry, for example—already developed inhibitors against the former could potentially be used to combat the latter.
T955 3667-3811 Sentence denotes But despite the efficacy demonstrated by many inhibitors of SARS‐CoV‐1, no specific prophylactic or postexposure therapy is currently available.
T956 3812-3870 Sentence denotes The first step in the viral life cycle is the viral entry.
T957 3871-3995 Sentence denotes It represents an attractive intervention point by blocking the RBD‐ACE2 interaction or the virus‐cell membrane fusion event.
T958 3996-4148 Sentence denotes A large number of inhibitors, including peptides, antibodies, small‐molecule compounds, and natural products have been identified to hamper viral entry.
T959 4149-4330 Sentence denotes Some of the peptides and antibodies displayed substantial anti‐SARS activity and are therefore considered promising entry inhibitors with high potencies in the low micromolar range.
T960 4331-4451 Sentence denotes Despite the apparent match of SARS‐CoV‐2 S and ACE2, other possible viral entry receptors should not be left unexplored.
T961 4452-4693 Sentence denotes The glucose‐regulated protein 78 (GRP‐78, aka HSPA5), for instance, is employed as a coreceptor for entry by several viruses, including bat‐CoVs and MERS‐CoV, 260 and a study predicted that SARS‐CoV‐2 S might utilize this mechanism as well.
T962 4694-4775 Sentence denotes 261 Elevated levels of GRP‐78 in COVID‐19 patients suggest a supplementary link.
T963 4776-4913 Sentence denotes 262 Although as of yet unconfirmed, the development of therapeutics against additional targets like GRP‐78 should receive due attention.
T964 4914-5073 Sentence denotes Viral proteases are another very important target for the development of antiviral therapies, as they are directly involved in the viral replication processes.
T965 5074-5252 Sentence denotes Especially the Mpro is one of the best‐characterized viral targets, and numerous medicinal chemistry efforts have been already reported for the past outbreaks of SARS‐1 and MERS.
T966 5253-5371 Sentence denotes Main proteases are highly conserved among other CoVs, which allows the development of broad spectral antiviral agents.
T967 5372-5428 Sentence denotes Moreover, no human protease analog to the Mpro is known.
T968 5429-5497 Sentence denotes Thus, drugs targeting Mpro could be highly virus‐selective and safe.
T969 5498-5670 Sentence denotes In light of the urgency of the current outbreak, repositioning of already approved drugs is becoming a popular approach due to the availability of toxicity and safety data.
T970 5671-5763 Sentence denotes Drug repurposing has become fashionable, promising quick solutions to complicated questions.
T971 5764-5825 Sentence denotes Old and, presumably, safe drugs are proclaimed miracle cures.
T972 5826-5857 Sentence denotes The reality is a different one:
T973 5858-6070 Sentence denotes Widely employed broad‐spectrum antiviral drugs, such as (hydroxy)chloroquine, favipiravir, ribavirin, or umifenovir were reported to be effective against SARS‐CoV‐2, but could not convince in clinical trials yet.
T974 6071-6185 Sentence denotes Clinicians are faced with an avalanche of contraindications and a myriad of case reports to choose the right drug.
T975 6186-6271 Sentence denotes The drug repositioning strategy is, therefore, not a sound scientific path to a cure.
T976 6272-6405 Sentence denotes At best, it can provide a basis for extensive future research in all related fields, including synthetic organic medicinal chemistry.
T977 6406-6506 Sentence denotes A new problem with the current COVID‐19 outbreak is related to the spread of scientific information.
T978 6507-6700 Sentence denotes When initial unfounded speculations about the alleged dangers of antihypertensive therapies with ACEis and ARBs were widely publicized in the media they caused great uncertainty among patients.
T979 6701-6810 Sentence denotes Impetuous communications such as these can have serious consequences and should not be proclaimed carelessly.
T980 6811-6946 Sentence denotes As it turns out, the benefits of continued antihypertensive therapy with these medicines in COVID‐19 patients far outweigh their risks.
T981 6947-7104 Sentence denotes There is even evidence of additional protective effects of ACEis and ARBs in this cohort, although the clinical relevance of this has yet to be investigated.
T982 7105-7294 Sentence denotes It is clear that governments and societies all over the world have been surprised by the recent coronavirus outbreak—as they were by the SARS outbreak in 2003 and the MERS epidemic in 2013.
T983 7295-7383 Sentence denotes Human‐infecting CoVs are on the rise, but quickly forgotten once life returns to normal.
T984 7384-7469 Sentence denotes However, this problem will not disappear by itself, but likely increase in intensity.
T985 7470-7576 Sentence denotes Viral spillover events are expected to increase in frequency as humans continue to invade new territories.
T986 7577-7721 Sentence denotes We hope that, this time, the world will heed nature's warning to finance and conduct groundbreaking research on CoVs and their disease patterns.
T987 7722-7859 Sentence denotes Only with a profound understanding of the viral life cycle and the affected human physiology we can prevent and control future outbreaks.