| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T51 |
0-104 |
Sentence |
denotes |
Fig. 1 HCoVs probably exhibit neuropathological consequences through multiple routes. ① Direct invasion. |
| T52 |
105-218 |
Sentence |
denotes |
After invasion, the production and release of virus may induce cell death by several pathways. ② Immune response. |
| T53 |
219-433 |
Sentence |
denotes |
The virus can lead to over-activation of host immune response, releasing a large number of pro-inflammatory cytokines and chemokines (e.g., IL-6, IL-1β, IL-2, IL-8, IL-17, G-CSF, GM-CSF, IP10, MCP1, CCL3, and TNF). |
| T54 |
434-552 |
Sentence |
denotes |
Cytokine signal pathways will subsequently induce the cell death and tissue damage. ③ Neuroendocrine-immune crosstalk. |
| T55 |
553-668 |
Sentence |
denotes |
Aberrant release of neuropeptides from the infected neurons may act at the endocrine glands, such as adrenal gland. |
| T56 |
669-816 |
Sentence |
denotes |
These neuropeptides might cause anomalous release of glucocorticoids and other peptides, which may contribute to the dysregulation of immune system |
