| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T37 |
0-145 |
Sentence |
denotes |
Cases have emerged in which patients had clinical manifestations of encephalitis and positive results of SARS-CoV-2 in cerebrospinal fluid (CSF). |
| T38 |
146-314 |
Sentence |
denotes |
However, these findings cannot prove the neurotropism of SARS-CoV-2 directly, since the CSF may also contain the virus from the meninges and cerebral microvasculatures. |
| T39 |
315-500 |
Sentence |
denotes |
In fact, based on the HPA and Genotype Tissue Expression (GTEx) databases, the CNS cells express rather low levels of TMPRSS2, which are required by SARS-CoV-2 for host cell entry [12]. |
| T40 |
501-661 |
Sentence |
denotes |
Lately, Bullen et al. reported the potential neurotropism of SARS-CoV-2 by employing a human induced pluripotent stem cell (iPSC)-derived BrainSphere mode [13]. |
| T41 |
662-828 |
Sentence |
denotes |
Virus infection and replication can be observed in BrainSphere despite the TMPRSS2 gene expression being below the detection limit, suggesting alternative processing. |
| T42 |
829-900 |
Sentence |
denotes |
In fact, a few proteins are found to act as co-factors for viral entry. |
| T43 |
901-1126 |
Sentence |
denotes |
A Disintegrin and Metalloproteases 17 (ADAM17) is a co-factor that can compete with TMPRSS2 or work independently for ACE2 shedding, and down regulation of ADAM17 by siRNA may result in a decreased in SARS-CoV infection [14]. |
| T44 |
1127-1228 |
Sentence |
denotes |
According to HPA database, ADAM17 is more widely distributed than TMPRSS2 in human brain tissue [12]. |
| T45 |
1229-1317 |
Sentence |
denotes |
Nevertheless, it should be emphasized that the current information is far from complete. |
| T46 |
1318-1615 |
Sentence |
denotes |
Several aspects still remain to be elucidated before drawing a final conclusion about the neurotropism of SARS-CoV-2, such as the potential host receptors and infection co-factors, the susceptibility of CNS resident cells, as well as possible host–pathogen interactions on ACE2/TMPRSS2 expression. |
