| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T508 |
0-205 |
Sentence |
denotes |
The polyphenolic structural motif of dietary polyphenols allows them to serve as excellent hydrogen bond donors which in turn help them to strongly interact with various biomacromolecules such as proteins. |
| T509 |
206-336 |
Sentence |
denotes |
This interaction is a critical step in the regulatory role of polyphenols on various key proteins involved in cellular physiology. |
| T510 |
337-482 |
Sentence |
denotes |
The majority, if not all, of the beneficial effect of polyphenols, can be explained via the functional consequence of proteins it interacts with. |
| T511 |
483-582 |
Sentence |
denotes |
Molecular target studies help us to predict therapeutic protein targets for a given small molecule. |
| T512 |
583-688 |
Sentence |
denotes |
Herein, we analyzed the predicted interacting proteins/enzymes for EGCG, TF2a, TF2b, TF3, and remdesivir. |
| T513 |
689-876 |
Sentence |
denotes |
This study is particularly important in the current context as we think that these polyphenols could target RdRp, an important enzyme that catalyzes the RNA replication in the SARS-CoV-2. |
| T514 |
877-1056 |
Sentence |
denotes |
Notably, the molecular target analysis suggests that all four polyphenols possess excellent properties of druggability, and they interact with a diverse class of proteins/enzymes. |
| T515 |
1057-1179 |
Sentence |
denotes |
The top 25 target classes of EGCG, TF2a, TF2b, TF3, and remdesivir are represented in the pie-chart, as shown in Figure 8. |
| T516 |
1180-1374 |
Sentence |
denotes |
The detailed output table with the target, common name, UniProt ID, ChEMBL ID, target class, probability, and known actives in 2D/3D are listed in Tables S7–S11 in the Supplementary Information. |
