LitCovid-sentences  

PMC:7441777 / 47825-49511 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T506 0-4 Sentence denotes 3.4.
T507 6-89 Sentence denotes Identification of target class for natural polyphenol via target prediction studies
T508 90-295 Sentence denotes The polyphenolic structural motif of dietary polyphenols allows them to serve as excellent hydrogen bond donors which in turn help them to strongly interact with various biomacromolecules such as proteins.
T509 296-426 Sentence denotes This interaction is a critical step in the regulatory role of polyphenols on various key proteins involved in cellular physiology.
T510 427-572 Sentence denotes The majority, if not all, of the beneficial effect of polyphenols, can be explained via the functional consequence of proteins it interacts with.
T511 573-672 Sentence denotes Molecular target studies help us to predict therapeutic protein targets for a given small molecule.
T512 673-778 Sentence denotes Herein, we analyzed the predicted interacting proteins/enzymes for EGCG, TF2a, TF2b, TF3, and remdesivir.
T513 779-966 Sentence denotes This study is particularly important in the current context as we think that these polyphenols could target RdRp, an important enzyme that catalyzes the RNA replication in the SARS-CoV-2.
T514 967-1146 Sentence denotes Notably, the molecular target analysis suggests that all four polyphenols possess excellent properties of druggability, and they interact with a diverse class of proteins/enzymes.
T515 1147-1269 Sentence denotes The top 25 target classes of EGCG, TF2a, TF2b, TF3, and remdesivir are represented in the pie-chart, as shown in Figure 8.
T516 1270-1464 Sentence denotes The detailed output table with the target, common name, UniProt ID, ChEMBL ID, target class, probability, and known actives in 2D/3D are listed in Tables S7–S11 in the Supplementary Information.
T517 1465-1474 Sentence denotes Figure 8.
T518 1476-1611 Sentence denotes Molecular target predictions for (A) EGCG, (B) TF2a, (C) TF2b (D) TF3, and (E) remdesivir obtained from swiss target prediction report.
T519 1612-1686 Sentence denotes The frequency of the target classes (top 25) is depicted in the pie chart.